ESTRO 2024 - Abstract Book

S1956

Clinical - Mixed sites, palliation

ESTRO 2024

Conclusion:

Among patients undergoing palliative SFRT, 30 day mortality rates were low, and comparable to prognostic variables associated with standard palliative radiation. Functional status is associated with 30-day mortality, hospitalization, and overall survival in patients receiving SFRT. Primary tumor type was not associated with overall mortality or hospitalization, but more disease sites with more aggressive histologies, such as anaplastic thyroid, head and neck SCC, and small cell lung cancer, demonstrated higher 30-day mortality than more generally indolent histologies. In this palliative setting, SFRT demonstrated 23.5% patient reported symptomatic palliation, comparable to previously reported symptom response in 26% of patients surviving less than 30 days 1 . In patients with poor functional status SFRT allows comparable palliation to conventional palliative approaches, but baseline patient status appears the dominant predictor of overall treatment course. Further refinement in patient selection for SFRT, compared with standard palliative approaches, is warranted.

Keywords: palliative, spatial fractionation, prognosis

References:

1. Park KR, Lee CG, Tseng YD, et al. Palliative radiation therapy in the last 30 days of life: A systematic review. Radiother Oncol. 2017;125(2):193-199. doi:10.1016/j.radonc.2017.09.016

2. Lee SF, Luk H, Wong A, Ng CK, Wong FCS, Luque-Fernandez MA. Prediction model for short-term mortality after palliative radiotherapy for patients having advanced cancer: a cohort study from routine electronic medical data. Sci Rep. 2020;10(1):1-10. doi:10.1038/s41598-020-62826-x 3. Nieder C, Stanisavljevic L, Mannsåker B, Haukland EC. Early death after palliative radiation treatment: 30-, 35- and 40-day mortality data and statistically robust predictors. Radiat Oncol. 2023;18(1):1-8. doi:10.1186/s13014 023-02253-0 4. Agrawal N, McClelland S, Shiue K, et al. Predictors of death for patients treated with palliative intent radiation using prospective databases. https://doi.org/101200/JCO20193715_suppl.e18325. 2019;37(15_suppl):e18325-e18325. doi:10.1200/JCO.2019.37.15_SUPPL.E18325 5. Mohiuddin M, Fujita M, Regine WF, Megooni AS, Ibbott GS, Ahmed MM. High-dose spatially-fractionated radiation (GRID): a new paradigm in the management of advanced cancers. Int J Radiat Oncol Biol Phys. 1999;45(3):721-727. doi:10.1016/S0360-3016(99)00170-4

2044

Digital Poster

Radiosurgery for Ventricular Tachycardia (RAVENTA): Treatment Characteristics of a Multicenter Trial

David Krug 1 , Adrian Zaman 2 , Melanie Grehn 1 , Judit Boda-Heggemann 3 , Boris Rudic 4 , Felix Mehrhof 5 , Leif-Hendrik Boldt 6 , Stephan Hohmann 7 , Roland Merten 8 , Dirk Rades 9 , Bettina Kirstein 10 , Stefanie Corradini 11 , Moritz Sinner 12 ,