ESTRO 2024 - Abstract Book

S1962

Clinical - Mixed sites, palliation

ESTRO 2024

occurred in 1 patient (3.3%) after lung SABR who developed a pericardial effusion that resolved without intervention. There was no acute grade 4-5 toxicity.

Conclusion:

The SMART ONE trial is the first prospective evaluation of single-fraction MR-guided adapted SABR that enrolled patients predominantly with mobile abdominal/pelvic tumors. Despite oART being frequently utilized to meet dosimetric objectives on the treatment day and the mandatory use of automatic beam gating, most patients completed treatment within 60 minutes and acute grade 3 toxicity was rare. As such, the primary feasibility and safety study objectives were both met. Secondary objective outcomes will be reported after the follow-up period matures.

Keywords: single fraction, ablative, MR Linac

2172

Digital Poster

Focused Ultrasound and RadioTHERapy for pain treatment in bone metastasis:an update of FURTHER trial

Federico Di Giammarco 1 , Renee Hovenier 2 , Jorik Slotman 3 , Alessio Giuseppe Morganti 4 , Martijn Boomsma 5 , Mira Maria Huhtala 6 , Erik Phernambucq 2 , Grischa Bratke 7 , Francesca De Felice 1 , Alessandro Napoli 1 , Alberto Bazocchi 8 , Roberto Blanco Sequeiros 9 , Heikki Minn 10 , Lambertus Bartels 2 , Milly Buwenge 4 , Chiara Gasperini 8 , Giulia Alfieri 1 , Ingrid Nijholt 5 , Holger Grull 7 , Manon Braat 2 , Chrit Moonen 2 , Sin Yuin Yeo 7 , Clement Bos 2 , Helena Verkooijen 2 1 Sapienza University of Rome - Policlinico Umberto I, Department of Radiological, Oncological and Pathological Sciences, Rome, Italy. 2 University Medical Centre Utrecht, Division of Imaging and Oncology, Utrecht, Netherlands. 3 Isala Hospital, Department of Radiology, Zwolle, Netherlands. 4 Alma Mater Studiorum - Bologna University, DIMES, Bologna, Italy. 5 Isala Hospital, Radiology, Zwolle, Netherlands. 6 University of Turku, Department of Oncology, Turku, Finland. 7 University of Cologne, Diagnostic and Interventional Radiology, Cologne, Germany. 8 IRCCS Istituto Ortopedico Rizzoli, Diagnostic and Interventional Radiology, Bologna, Italy. 9 Turku University Hospital, Radiology, Turku, Finland. 10 University of Turku, Radiology, Turku, Finland

Purpose/Objective:

Patients with advanced cancer often experience interference of their everyday functioning and quality of life due to bone metastasis. Palliative external beam radiation therapy (EBRT) is the standard of care for these patients. Although EBRT is an effective therapeutic option, 20-30% of patients do not respond to EBRT, and it can take up to 4-6 weeks to produce the best pain reduction. In this context, magnetic resonance image guided high intensity focused ultrasound (MRI-HIFU) may represent a valid treatment option, as it has been shown to induce rapid pain relief in up to 60-70% of patients.