ESTRO 2024 - Abstract Book

S2016

Clinical - Paediatric

ESTRO 2024

The compilation of national guidelines on palliative radiotherapy in children and the subsequent work with spreading the information in different relevant occupational categories across the country has increased the knowledge of palliative radiotherapy in the Swedish paediatric oncology community. The guidelines facilitate decision making in the palliative setting and we believe that the guidelines in combination with educational efforts on the topic will result in more paediatric patients receiving appropriate palliative radiotherapy.

Keywords: palliative radiotherapy, national guidelines

168

Proffered Paper

Subsequent colorectal cancer in survivors of childhood cancer: RT dose-volume & chemotherapy effects

Constance A Owens 1 , Ethan B Ludmir 2,3 , Weiyu Qiu 4 , Qi Liu 4 , Susan A Smith 1 , Bastien Rigaud 1 , Kristy K Brock 1,5 , James E Bates 6 , Taylor G Meyers 1 , Arnold C Paulino 7 , Christine B Peterson 1 , Stephen F Kry 1 , Joseph P Neglia 8 , Wendy M Leisenring 9,10 , Kevin C Oeffinger 11 , Paul C Nathan 12 , Lucie M Turcotte 8 , David Hodgson 13 , Melissa M Hudson 14 , Leslie L Robison 15 , Chaya Moskowitz 16 , Gregory T Armstrong 15 , Yutaka Yasui 15 , Tara O Henderson 17 , Rebecca M Howell 1 1 The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, Houston, USA. 2 The University of Texas MD Anderson Cancer Center, Department of Gastrointestinal Radiation Oncology, Houston, USA. 3 The University of Texas MD Anderson Cancer Center, Department of Biostatistics, Houston, USA. 4 University of Alberta, Department of Public Health Sciences, Edmonton, Canada. 5 The University of Texas MD Anderson Cancer Center, Department of Imaging Physics, Houston, USA. 6 Emory University, Department of Radiation Oncology, Atlanta, USA. 7 The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology, Houston, USA. 8 University of Minnesota, Department of Pediatrics, Minneapolis, USA. 9 Fred Hutchinson Cancer Center, Clinical Research Division, Seattle, USA. 10 Fred Hutchinson Cancer Center, Public Health Sciences Division, Seattle, USA. 11 Duke University, Department of Medicine, Durham, USA. 12 The Hospital for Sick Children, Division of Paediatric Hematology/Oncology, Toronto, USA. 13 University of Toronto, Department of Radiation Oncology, Toronto, Canada. 14 St. Jude Children’s Research Hospital, Department of Oncology, Memphis, USA. 15 St. Jude Children’s Research Hospital, Department of Epidemiology and Cancer Control, Memphis, USA. 16 Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, New York, USA. 17 The University of Chicago, Department of Pediatrics, Chicago, USA

Purpose/Objective:

Abdomen and pelvis radiation therapy (RT) and chemotherapy are well-established risk factors for colorectal subsequent malignant neoplasms (SMN) in survivors of childhood cancer. However, the relationship between RT dose and dose-volume metrics for the colorectum and its substructures and the association between these metrics and chemotherapy have not been well described in this population. We aimed to quantify the RT dose volume effect and the chemotherapy interaction effect.

Material/Methods: