ESTRO 2024 - Abstract Book

S2026

Clinical - Paediatric

ESTRO 2024

Conclusion:

Hematologic toxicity is a frequent acute side effect of CSI, with severity increasing with higher mean doses delivered to the hematogenous BM and larger volumes of BM receiving 30 or 35Gy. However, toxicities didn’t lead to treatment abandonment or life-threatening complications in our cohort. Identifying dose/volume thresholds could help in developing dose constraints and recommendations on reducing the risks of such events, but further studies are required to validate our findings.

Keywords: Craniospinal irradiation, Hematologic toxicity

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Paediatric total body irradiation using VMAT in an upper-middle income asian country

Nisha Shariff 1 , Zulaikha Jamalludin 2 , Ngie Min Ung 2 , David DW Lee 2 , Munira M Rejab 1 , Aik Hao Ng 2

1 University Malaya Medical Centre, Department of Clinical Oncology, Kuala Lumpur, Malaysia. 2 University Malaya, Faculty of Medicine, Kuala Lumpur, Malaysia

Purpose/Objective:

Total body irradiation (TBI) is a recognised method for conditioning prior to bone marrow transplantation due to survival benefit over chemo-conditioning in acute lymphoblastic leukaemia. Conventional methods of TBI require sophisticated equipment and larger radiotherapy bunker sizes which may not be available in modern