ESTRO 2024 - Abstract Book

S2028

Clinical - Paediatric

ESTRO 2024

Given the twice a day scheduling required for TBI and treatment time, more treatment slots on the LINAC were occupied which posed a challenge in our centre with two LINAC. To overcome this, radiation therapists were asked to work longer hours on rotation to ensure the overall patient service delivery was not compromised.

Conclusion:

TBI with VMAT is achievable with standard linear accelerators available in most middle-income countries. Effective treatment demands robust IGRT techniques and rigorous quality assurance to ensure accurate delivery of a plan with multiple isocentres.

Keywords: Body irradiation, paediatric, VMAT

References:

1) Peters C, Dalle JH, Locatelli F et al. Total Body Irradiation or Chemotherapy Conditioning in Childhood ALL: A Multinational, Randomized, Noninferiority Phase III Study. J Clin Oncol. 2021 Feb 1;39(4):295-307.

2) Hoeben BAW, Pazos M, Seravalli E et al. ESTRO ACROP and SIOPE recommendations for myeloablative Total Body Irradiation in children. Radiother Oncol. 2022 Aug;173:119-133.

827

Proffered Paper

Study of the impact of pediatric irradiation on memory-related areas microstructure (NCT04324450)

Fatima TENSAOUTI 1,2 , Germain Arribarat 2 , Bastien Cabarrou 3 , Lisa Pollidoro 2,4 , Patrice Péran 2 , Yves Chaix 4,2 , Eloïse Baudou 2,4 , Anne Laprie 1,2 1 Oncopole Claudius REGAUD, institut Universitaire du Cancer de Toulouse-Oncopole, Radiation Oncology, Toulouse, France. 2 ToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Research, Toulouse, France. 3 Oncopole Claudius REGAUD, institut Universitaire du Cancer de Toulouse-Oncopole, Biostatistics & Health Data Science Unit, Toulouse, France. 4 Children's Hospital, Toulouse University Hospital, Pediatric Neurology, Toulouse, France

Purpose/Objective:

Posterior fossa tumor (PFT) account for approximately half of all central nervous system (CNS) tumors in children [1]. Despite a high rate of cure, many survivors experience long-term neurocognitive sequelae [2]. This is because patients are affected not only by the tumor itself but also by the different treatments received (surgery, chemotherapy and radiotherapy (RT)). The aim of this work is to investigate the long-term impact of irradiation dose on memory brain structure integrity using diffusion tensor imaging (DTI) and consequence on memory performances.