ESTRO 2024 - Abstract Book

S2030

Clinical - Paediatric

ESTRO 2024

performances did not significantly differ in visual anterograde memory (face recognition), autobiographical memory and semantic memory.

MD values correlated significantly with related memory scores in cerebellum (visual and verbal working memory, (r<-0.63, p<0.02) and in right hippocampus (episodic memory and EPIREAL, r<-0.5, p<0.01).

Conclusion:

DTI showed microstructure alterations in memory-related areas. Indeed, DTI metrics values were significantly different between groups and a significant correlation was found with doses to cerebellum and left caudate nucleus. In the other hand, memory performances in all PFT survivors, especially in irradiated group, were lower compared to control group and were correlated to DTI metrics values. These preliminary results (i) indicate that radiotherapy affects the microstructure of specific cerebral structures and (ii) identify DTI as a potential biomarker of structure-dependent memory deficit.

Keywords: Posterior fossa tumor, memory, DTI

References:

[1] Mengide JP., et al. Posterior fossa tumors in children: An update and new concepts. Surg Neurol Int. 2023 Mar 31;14:114. doi: 10.25259/SNI_43_2023. PMID: 37151431; PMCID: PMC10159277.

[2] Baudou E., et al. A review of long-term deficits in memory systems following radiotherapy for pediatric posterior fossa tumor. Radiotherapy and Oncology. https://doi.org/10.1016/j.radonc.2022.05.022

[3] Baudou E., et al. A prospective behavioral and imaging study exploring the impact on long-term memory of radiotherapy delivered for a brain tumor in childhood and adolescence. Clin Transl Radiat Oncol. 2021 Nov 7;33:7 14. doi: 10.1016/j.ctro.2021.10.006.

[4] Baudou, E., et al. "MO-0551 Impact of pediatric irradiation on connectivity in learning and memory circuits (NCT04324450)." Radiotherapy and Oncology 182 (2023): S432.

[5]Tensaouti F., et al. Perfusion MRI and MRI spectroscopy: biomarkers of memory decline in pediatric brain tumor survivors. ISSN: 0167-8140 , 1879-0887; DOI: 10.1016/S0167-8140(23)66363-7. Radiotherapy and oncology, 2023, Vol.182, p.S1173-S1174

[6] Troudi A., et al, A Prospective Study of Arterial Spin Labelling in Paediatric Posterior Fossa Tumour Survivors: A Correlation with Neurocognitive Impairment, Clinical Oncology, 2023, https://doi.org/10.1016/j.clon.2023.09.015.

[7] Lemesle, B., et al. Hidden objective memory deficits behind subjective memory complaints in patients with temporal lobe epilepsy. Neurology. 2022 Feb 22;98(8):e818-e828. doi: 10.1212/WNL.0000000000013212.

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