ESTRO 2024 - Abstract Book

S2041

Clinical - Paediatric

ESTRO 2024

0.9 (0.7 - 1.2) 0.6 (0.3 - 1.2) 0.8 (0.4 - 1.5)

1.6 (0.9 - 3.1) 1.1 (0.6 - 2.0) 1.4 (1.0 - 2.2)

3.3 (1.8 - 6.2)* 2.3 (1.3 - 4.1)* 3.0 (2.3 - 3.8)* 4.2 (2.8 - 6.3)*

<5

5 – 9.9

Mean whole heart

10

–

3.2 (2.2 - 4.8)* 4.6 (3.5 - 6.0)* 4.3 (2.7 - 6.9)*

4.7 (2.8 - 7.8)*

19.9

radiation dose (Gy)

20

–

6.6 (4.5 - 9.9)*

29.9

6.2 (4.7 - 8.1)*

≥30

* represents statistically significant at the p < 0.05 level

Figure 1 . Excess relative rate dose-response models between mean whole heart radiation dose (A) and mean LAD radiation dose (B) and risk of any cardiac disease.

Conclusion:

Considering cardiac substructure doses (especially the LAD) in addition to mean whole heart doses may enhance prediction of late cardiac morbidity in survivors of childhood cancer. When developing pediatric treatment plans, radiation oncologists should consider doses to the cardiac substructures to minimize late cardiac risk.

Keywords: cardiac toxicity, late effects, heart radiation

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