ESTRO 2024 - Abstract Book

S2078

Clinical - Sarcoma, skin cancer, melanoma

ESTRO 2024

institutional experience to evaluate the impact of hypofractionation on pathological response and the acute RT related toxicity.

Material/Methods:

From August 2021 to July 2023, 14 patients with limb or trunk STS underwent hypofractionated preoperative RT (HFRT) in two treatment schemes: 30 Gy in 5 fractions (ultra hypofractionated RT, U-HFRT) and 42,75Gy in 15 fractions (moderate hypofractionated RT, M- HFRT). A favorable pathologic response (fPR) was considered as ≥ 80% of necrosis and/or percentage of viable tumor <25% on specimen examination.

Results:

All patients completed RT treatment with no interruptions. Seven patients (50%) were treated with U-HFRT. Median tumor size was 10,2 cm. Mean time between end of RT and surgery was 4.6 weeks. Nine patients (64,3 %) achieved a fPR. No patient developed ≥ grade 3 acute skin toxicity during RT or within 4 weeks after; 10 patients 71,4%) grade 1-2 acute skin toxicity. Three patients (21,4%) had acute major wound complications (including: 1 secondary intervention for wound repair and 2 cases of prolonged wound care).

Conclusion:

Preoperative hypofractionated RT treatment for STS is feasible, well tolerated, without greater acute toxicity compared with normofractionated RT, and associates encouraging rates of pathologic response.

Keywords: Hypofractionation, Preoperative radiotherapy, STS

References:

1. Guadagnolo, B Ashleigh et al. Hypofractionated, 3-week, preoperative radiotherapy for patients with soft tissue sarcomas (HYPORT-STS): a single-centre, open-label, single-arm, phase 2 trial. The Lancet Oncology, Volume 23, Issue 12, 1547 - 1557, 2022. 2. M Bedi, R Singh et al. Is 5 the New 25? Long-Term Oncologic Outcomes From a Phase II, Prospective, 5-Fraction Preoperative Radiation Therapy Trial in Patients With Localized Soft Tissue Sarcoma. Advances in Radiation Oncology, Volume 7, Issue 3, 2022.

492

Digital Poster

Prevalence and trends of non melanoma skin cancer abstracts at annual ESTRO congresses