ESTRO 2024 - Abstract Book

S2103

Clinical - Sarcoma, skin cancer, melanoma

ESTRO 2024

margin ranging from 5-10mm depending on histological subtype. Patients were offered a single follow-up visit six months after completion of treatment. Patient reported satisfaction with cosmetic outcome was scored as: very satisfied, satisfied, indifferent, or unsatisfied. Professional scoring was based on LENTSOMA-criteria with an overall cosmetic score reported as: no, minor, major, or disfiguring skin changes, compared to the surrounding skin.

Results:

In total, 1133 patients were registered, of which 738 (65%) with follow-up information were included in the study. Patient, tumor, and treatment related factors are shown in table 1. Overall, 711 (96%) of the patients reported to be either very satisfied or satisfied with the cosmetic outcome six-nine months after the end of treatment. This was highly correlated with the overall professional evaluation of the cosmetic outcome (p<0.001), where 97% of cases were described as having either no or minor skin changes in the radiation field when compared to surrounding skin.

In univariate analysis, patient satisfaction with cosmetic outcome was not related to age (p=0.5), sex (p=0.4), or smoking (p=0.5). The same pattern was reflected using evaluation by professionals as endpoint.

In patients with tumor located on the nose, 71% (409) reported to be very satisfied compared to 53% of patients with tumors in other facial locations(p<0.001). Patient-reported and overall professional evaluation did not differ significantly by field size (p=0.4 and p=0.5 respectively). Field size ≥2.5 cm was associated with a higher degree of dyspigmentation (p=0.05) when reported by professionals. Comparison of fraction size (3 Gy/fx vs 4.5 Gy/fx) revealed no significant difference in patient reported cosmetic outcome (p=0.3), which again was in accordance with the overall professional evaluation (p=0.8). In a linear regression analysis of patients with complete information on all parameters (N=636), neither age, sex, smoking, field size, nor fractionation were independent significant factors for patient satisfaction six months after radiotherapy. However, increasing field size (p=0.04), current smoking (p=0.01), and increasing age (p=0.05) were associated with worse professional scoring.

All

patients

Patients

with

follow-up

N=1128

N=738

Age (Median)

74 years [33-96y]

73.5 years [33-96y]

Sex

Male

472 (42%)

319 (43%)

Female

656 (58%)

419 (57%)

Smoking status

Current/former smoker

328 (29%)

226 (31%)

Never smoker

596 (53%)

410 (56%)

Unknown

204 (18%)

102 (14%)

Tumor location

Nose

900 (80%)

579 (79%)

Other facial regions

228 (20%)

159 (21%)

Tumor stage