ESTRO 2024 - Abstract Book

S2131

Clinical - Upper GI

ESTRO 2024

To assess the effect of poor nutritional status on treatment tolerance and the rates of treatment completion in patients with carcinoma of the oesophagus undergoing neoadjuvant chemoradiation.

Material/Methods:

This retrospective study aimed to assess the impact of nutrition on treatment tolerance and proposed treatment completion rates in patients diagnosed with Carcinoma Esophagus who underwent neoadjuvant chemoradiation over three years.

Data Collection:

Patient Selection: A total of 58 patients diagnosed with locally advanced squamous cell carcinoma of the oesophagus who received neoadjuvant chemoradiation 41.4 – 50.4 Gy along with weekly 5 cycles of chemotherapy consisting of platin and taxanes were included in the analysis.

Nutritional Assessment: Each patient's nutritional status was assessed at the beginning of neoadjuvant therapy in oesophageal cancer. This assessment included parameters such as body weight and dietary intake records.

Treatment Protocol: Details of the neoadjuvant chemoradiation regimen were recorded, including chemotherapy agents, radiation doses, and the duration of treatment.

Surgical Outcomes: Data regarding surgical interventions, including the number of patients who proceeded to surgery and those who did not, were documented.

Statistical Analysis:

Descriptive Statistics: Baseline Characteristics, Nutritional status and treatment regimens were summarized using descriptive statistics.

Impact Assessment: The effect of poor nutritional status on treatment tolerance and completion rates was analyzed using chi-squared tests and logistic regression analysis, where appropriate.

Outcome Analysis: The outcomes were reported as frequencies and percentages, including the number of patients who successfully completed treatment and those who experienced compromised treatment tolerance.

Results:

In our study, which included 58 patients with squamous cell carcinoma of the oesophagus. The mean age was 62.2±10 years. In our study, the baseline weight measured at the outset averaged 46.2 ± 2 kilograms. Patients’ mean weight loss was 3.42±2.4 kilograms during neoadjuvant chemoradiation. Forty-seven individuals successfully completed the planned neoadjuvant chemoradiation regimen. Among these patients, 25 (43%) subsequently underwent surgical intervention as part of their treatment plan. However, a significant portion of the cohort, specifically 22 patients (37%), did not proceed with surgery due to the challenges posed by poor nutritional status during the course of chemoradiation. Tragically, 11 patients (18%) in our study expired as a direct consequence of their compromised tolerance to the treatment, primarily attributed to their inadequate nutritional status at the commencement of neoadjuvant therapy (excluded from this study). These findings underscore the critical