ESTRO 2024 - Abstract Book

S2136

Clinical - Upper GI

ESTRO 2024

Conclusion:

Radiation-induced severe lymphopenia is associated with inferior OS for HCC patients treated by SBRT. Larger liver V5Gy and V10Gy were associated with higher incidence of radiation-induced severe lymphopenia. During radiotherapy planning, methods should be used to minimize the low dose scatter to the liver to minimize damage to the circulating lymphocytes.

Keywords: HCC, SBRT, Lymphopenia

References:

1. Lewis S, Dawson L, Barry A, Stanescu T, Mohamad I, Hosni A. Stereotactic body radiation therapy for hepatocellular carcinoma: From infancy to ongoing maturity. JHEP Rep. 2022;4(8):100498.

2. Chiang CL, Chiu KWH, Chan KSK, Lee FAS, Li JCB, Wan CWS, Dai WC, Lam TC, Chen W, Wong NSM, Cheung ALY, Lee VWY, Lau VWH, El Helali A, Man K, Kong FMS, Lo CM, Chan AC. Sequential transarterial chemoembolisation and stereotactic body radiotherapy followed by immunotherapy as conversion therapy for patients with locally advanced, unresectable hepatocellular carcinoma (START-FIT): a single-arm, phase 2 trial. Lancet Gastroenterol Hepatol. 2023;8(2):169-78.

3. Vaes RDW, Hendriks LEL, Vooijs M, De Ruysscher D. Biomarkers of Radiotherapy-Induced Immunogenic Cell Death. Cells. 2021;10(4).