ESTRO 2024 - Abstract Book

S2149

Clinical - Upper GI

ESTRO 2024

Conclusion:

The incidence of (post-operative) pneumonia was significantly lower among patients treated with PRT as compared to PhRT. Next to radiation technique, baseline COPD was an independent predictor for this endpoint. The reduction among those treated with PRT is attributed to both the lower mean dose in heart and lungs (PC1) as well as the reduced exposure to low doses in the heart and lungs (PC3), highlighting that PRT reduced the risk of pneumonia through dose reductions in multiple anatomical structures.

Keywords: Proton-therapy, Oesophageal cancer, Pneumonia

References:

1. Thomas, M. et al. NTCP model for postoperative complications and one-year mortality after trimodality treatment in oesophageal cancer. Radiother. Oncol. J. Eur. Soc. Ther. Radiol. Oncol. 141, 33 – 40 (2019).

2. Shiraishi, Y., Xu, C., Yang, J., Komaki, R. & Lin, S. H. Dosimetric comparison to the heart and cardiac substructure in a large cohort of esophageal cancer patients treated with proton beam therapy or Intensity modulated radiation therapy. Radiother. Oncol. 125, 48 – 54 (2017).

3. Hirano, Y. et al. Dosimetric comparison between proton beam therapy and photon radiation therapy for locally advanced esophageal squamous cell carcinoma. Radiat. Oncol. 13, 23 (2018).