ESTRO 2024 - Abstract Book

S2168

Clinical - Upper GI

ESTRO 2024

SM1 in 5 patients, and SM2 in 8 patients. LVI was noted in 19 patients. The median follow-up period was 74 (28 – 123) months. The 3-year and 5-year overall survival rates were 92% and 78%, respectively, whereas the 3-year and 5-year progression-free survival rates were 83% and 70%, respectively. Progression was detected in four patients (local recurrence in one, lymph node metastasis in two, and distant metastasis in one). Grade 2 esophageal stenosis occurred in eight (33%) patients. There was no case of Grade 3 or worse esophageal stenosis. Among them, four (17%) patients developed stenosis before additional CRT, which persisted following the completion of additional CRT. The remaining four (17%) patients developed new-onset stenosis within five months after the completion of additional CRT. One patient (4%) still requires regular bougie dilation. Grade 3 and Grade 4 acute toxicity, including anemia, neutropenia, thrombocytopenia, and meningitis occurred in one (4%) and zero (0%), six (25%) and one (4%), one (4%) and zero (0%), and one (4%) and zero (0%) patients, respectively. A late toxicity manifestation, Grade 2 pericardial effusion, was observed in three (13%) patients; however, no Grade 3 or worse pericardial effusion was observed. None of these patients had symptomatic radiation pneumonitis. No Grade 5 toxicity was observed.

Conclusion:

Additional CRT is a viable treatment option even in patients who have undergone near-circumferential or full circumferential noncurative ESD, as well as in those with limited diseases. Additional CRT toxicity (including esophageal stenosis) is manageable and acceptable.

Keywords: chemoradiotherapy, esophageal cancer, ESD

References:

1. Minashi K, Nihei K, Mizusawa J, et al (2019) Efficacy of Endoscopic Resection and Selective Chemoradiotherapy for Stage I Esophageal Squamous Cell Carcinoma. Gastroenterology 157:382-390.e3. https://doi.org/10.1053/j.gastro.2019.04.017

2. Nishibuchi I, Murakami Y, Adachi Y, et al (2020) Effectiveness of salvage radiotherapy for superficial esophageal Cancer after non-curative endoscopic resection. Radiat Oncol 15:133. https://doi.org/10.1186/s13014-020-01582-8

3. Hisano O, Nonoshita T, Hirata H, et al (2018) Additional radiotherapy following endoscopic submucosal dissection for T1a-MM/T1b-SM esophageal squamous cell carcinoma improves locoregional control. Radiat Oncol 13:14. https://doi.org/10.1186/s13014-018-0960-y

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Established a nomogram for predicting anastomotic leakage after trimodality therapy for ESCC

wei-xiang Qi, Shuyan li, Huan Li, shengguang zhao, jiayi chen

ruijin Hospital,shanghai jiaotong university school of medicine, radiation oncology, shanghai, China