ESTRO 2024 - Abstract Book

S2178

Clinical - Upper GI

ESTRO 2024

Figure 1. Kaplan-Meier analysis for absolute lymphocyte count (ALC) in week 3 for overall survival.

Conclusion:

This study demonstrates that the absolute lymphocyte count in week 3 of CRT for esophageal cancer (at a threshold of 0.5 x103/μL) is the strongest metric for radiation -induced lymphopenia to distinguish survival outcomes. Hence, endeavors to improve on the metric ALC week 3 could be aimed for in lymphopenia-mitigating strategies and future trials, with the ultimate goal to improve survival.

Keywords: radiation-induced lymphopenia, esophageal cancer

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Digital Poster

Enhancing outcomes: Neoadjuvant chemoradiation in locally advanced operable esophageal cancer.

Sam David 1 , Naveen Mummudi 1 , Anil Tibdewal 1 , Sabita Jiwnani 2 , Trupti Pai 3 , Jai Prakash Agarwal 1

1 Tata Memorial Hospital, Department of Radiation Oncology, Mumbai, India. 2 Tata Memorial Hospital, Department of Surgical Oncology, Mumbai, India. 3 Tata Memorial Hospital, Department of Pathology, Mumbai, India

Purpose/Objective:

Neoadjuvant chemoradiation (NACTRT) followed by surgery has been established as the standard of care in locally advanced operable carcinoma esophagus (1). This approach has resulted in better pathological complete response rates and survival outcomes without significantly increasing surgical morbidities or treatment-related mortality.