ESTRO 2024 - Abstract Book

S2299

Clinical - Urology

ESTRO 2024

1 Consorci Sanitari de Terrassa, Radiation Oncology, Terrassa, Spain. 2 Consorci Sanitari de Terrassa, Epidemiology, Terrassa, Spain

Purpose/Objective:

The incidence of fecal incontinence (FI) after moderately hypofractionated radiotherapy to the prostate remains poorly studied.

This is a prospective follow-up cohort study of patients with prostate cancer who underwent moderately hypofractionated volumetric modulated arc therapy (VMAT), 2.5-3.0Gy/fraction, with image-guided radiotherapy (IGRT) in a real clinical practice setting.

The main objective of this work was to describe the incidence of FI and the time of occurrence of the event in this group of patients.

Second, to analyze whether or not this late radiotoxicity affected quality of life (QL)

Material/Methods:

The incidence of FI was reported using the Vaizey score, and FI-free survival after completion of radiotherapy was analyzed using the non-parametric Kaplan-Meier test.

On the other hand, we recorded the FI QoL scores (Spanish validated FIQL scale) of all the included patients and the non-parametric Mann-Whitney U test for independent samples was performed to analyze whether the FI influenced the QoL scores

Results:

The total sample included in the study was 91 patients.

Two years after completion of radiotherapy, 10 of 91 patients (11%) showed some degree of FI. In the cases in which FI appeared, it occurred at an average of 13.6 months (range: 3.4-22.3).

Patients with some degree of FI according to the Vaizey scale had worse FIQL scores than those without FI, notably for lifestyle (p<0,001), behaviour (p<0,001), shame (p<0,05) and global (p<0,001) scores

Conclusion:

Despite technical advances in radiotherapy for prostate cancer, our patients had a significant incidence of FI after moderately hypofractionated VMAT/IGRT, and this late toxicity impacted their QoL

Keywords: Prostate cancer, VMAT, fecal incontinence