ESTRO 2024 - Abstract Book

S2385

Clinical - Urology

ESTRO 2024

18 F-flotufolastat and 18 F-rhPSMA-7 PET-guided SRT results in more favorable disease outcomes than C-SRT without PET. In our preliminary analysis, statistical significance was not reached, most likely due to the limited sample size. However, these data illustrate the potential for 18 F-flotufolastat PET-guided SRT to be considered as part of personalized radiotherapeutic management of patients with PSMA-PET-positive local pelvic relapse after RP.

Keywords: Prostate cancer, Salvage Radiotherapy, PSMA-PET

1054

Digital Poster

A multicenter study on prophylactic nodal irradiation in salvage radiotherapy of prostate cancer.

Erika Galietta 1,2 , Letizia Cavallini 1,2 , Filippo Mammini 1,2 , Silvia Paolinelli 1,2 , Viola Laghi 1,2 , Elena Natoli 1,2 , Milly Buwenge 1 , Giorgio Coco 1,2 , Alessandra D'Alterio 1,2 , Pietro Del Pia 1 , Nadav Schindler 1 , Noam Shira Darnell 1 , Arthur Sarmento Pinto Yanez 1 , Maria Ntreta 2 , Gabriella Macchia 3 , Francesco Deodato 3,4 , Annalisa Cortesi 5 , Selena Ciabatti 6 , Michele Benedetti 7 , Antonio Malorgio 8 , Ilaria Moschini 9 , Francesca Maurizi 10 , Savino Cilla 11 , Alessio Giuseppe Morganti 1,2 , Alessandra Arcelli 2 1 Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy. 2 Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. 3 Radiation Oncology Unit, Gemelli Molise Hospital-Università Cattolica del Sacro Cuore, Campobasso, Italy. 4 Istituto di Radiologia, Università Cattolica del Sacro Cuore, Roma, Italy. 5 Radiotherapy Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy. 6 Radiotherapy Department, Ospedale Bellaria, Bologna, Italy. 7 Radiotherapy Unit, Ospedale Infermi, Rimini-AUSL Romagna, Italy. 8 Department of Radiotherapy, Azienda Ospedaliero-Universitaria di Ferrara, Ferrara, Italy. 9 Radiotherapy Department, Azienda Ospedaliera di Piacenza, Piacenza, Italy. 10 Radiation Oncology, A.O. Ospedali Riuniti Marche Nord, Pesaro, Italy. 11 Medical Physics Unit, Gemelli Molise Hospital, Università Cattolica del Sacro Cuore, Campobasso, Italy

Purpose/Objective:

Salvage radiotherapy (SRT) is the standard treatment for prostate cancer (PCa) patients who experience biochemical recurrence after radical prostatectomy. The use of prophylactic nodal irradiation (PNI) in this context remains a topic of debate. The primary objective of this study is to assess the prognostic impact of PNI in PCa patients undergoing SRT by conducting a comprehensive analysis of patient, tumor, and treatment-related parameters.

Material/Methods:

The study examined various endpoints, including biochemical relapse-free survival (bRFS), local control (LC), regional control (RC), metastasis-free survival (MFS), disease-free survival (DFS), and overall survival (OS). Data from PCa patients treated with SRT for biochemical recurrence were obtained from a multicenter observational study. Univariate (log-rank) and multivariate (Cox) analyses were carried out, incorporating parameters related to patient characteristics (e.g., age and Charson's comorbidity index), tumor characteristics (e.g., PSA levels before surgery and SRT, ISUP grade, pT stage, pN stage), and treatment specifics (e.g., PNI, seminal vesicles irradiation, prior TURP, ADT