ESTRO 2024 - Abstract Book

S2397

Clinical - Urology

ESTRO 2024

Keywords: Prostate, Stereotactic, Hydrogel spacer

References: 1 www.clinicaltrials.gov/study/NCT4905069

1140

Digital Poster

Updated analysis on mpMRI sensitivity in detecting prostate bed recurrences pre-salvage radiotherapy

Letizia Cavallini 1,2 , Caterina Gaudiano 3 , Beniamino Corcioni 3 , Lorenzo Bianchi 1,4 , Riccardo Schiavina 1,4 , Eugenio Brunocilla 1,4 , Erika Galietta 1,2 , Filippo Mammini 1,2 , Silvia Paolinelli 1,2 , Viola Laghi 1,2 , Elena Natoli 1,2 , Alessandra D'Alterio 1,2 , Giorgio Coco 1,2 , Silvia Bisello 5 , Francesco Deodato 6,7 , Gabriella Macchia 6 , Tigeneh Wondemagegnhu 8 , Alessandra Arcelli 2 , Alessio Giuseppe Morganti 1,2 , Maria Ntreta 2 1 Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy. 2 Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. 3 Department of Radiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. 4 Division of Urology, IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, Italy. 5 Radiation Oncology, Azienda Ospedaliero-Universitaria Ospedali Riuniti di Ancona, Ancona, Italy. 6 Radiation Oncology Unit, Gemelli Molise Hospital-Università Cattolica del Sacro Cuore, Campobasso, Italy. 7 Istituto di Radiologia, Università Cattolica del Sacro Cuore, Roma, Italy. 8 Radiotherapy Department, Tikur Anbessa Specialized Hospital, Department of Clinical Oncology, College of Medicine and Health Sciences, University of Gondar, Addis Ababa, Ethiopia, Addis Ababa, Ethiopia

Purpose/Objective:

The observational study aimed to investigate the potential role of multiparametric magnetic resonance imaging (mpMRI) in prostate cancer (PCa) patients who were candidates for salvage radiotherapy (sRT) following biochemical recurrence after radical prostatectomy.

Material/Methods:

The study included 91 PCa patients. The median age of the patients was 67 years, with a range of 41 to 78. The median PSA level at biochemical recurrence was 0.4 ng/ml, ranging from 0.01 to 6.24 ng/ml (interquartile range: 0.22-1.04). Most patients (75.8%) had high-grade ISUP scores (3-5). All patients underwent clinical and instrumental evaluations, including pelvic mpMRI with an endorectal coil.

Results:

mpMRI detected macroscopic local recurrences in 54 out of 91 patients (59.3%). Of these local recurrences, 68.5% were located at the bladder neck, 20.4% at the vesicourethral anastomosis, 9.2% in the recto-vesical space, and