ESTRO 2024 - Abstract Book

S2460

Clinical - Urology

ESTRO 2024

Conclusion:

Large interfraction displacements have been observed in the bladder trigone among PCa patients treated with moderate hypofractionated radiotherapy, mostly occurring in the AP axis and strongly correlated to the bladder volume. Incorporation of a bladder-trigone PRV structure for treatment planning optimization can be considered for a “trigone - sparing” radiotherapy approach aiming to further reduce radiation -induced toxicity of PCa patients.

Keywords: Trigone,Prostate,Radiotherapy

1819

Digital Poster

A RCT on lifestyle and microbiota in prostate cancer pts undergoing RT: MICROSTYLE study.

Ilaria Repetti 1,2 , Giulia Marvaso 1 , Giulia Corrao 1 , Chiara Lorubbio 1,2 , Patrizia Gnagnarella 3 , Harriet Johansson 4 , Paolo Muto 5 , Valentina Borzillo 5 , Egidio Celentano 6 , Anna Crispo 6 , Monica Pinto 7 , Ernesta Cavalcanti 8 , Barbara Summa 3 , Francesco Labonia 8 , Giuseppe Porciello 6 , Melania Prete 5 , Maria Grimaldi 6 , Oriana D'ecclesiis 3 , Dario Zerini 9 , Rossella Di Franco 5 , Nunzio De Martino 5 , G. S. Mercogliano 5 , Barbara Alicja Jereczek-Fossa 9,2 , Sara Gandini 3 1 European Institute of Oncology IRCSS, Division of Radiotherapy, Milan, Italy. 2 University of Milan, Department of Oncology and Hemato-oncology, Milan, Italy. 3 European Institute of Oncology IRCSS, Division of Epidemiology and Biostatistics, Milan, Italy. 4 European Institute of Oncology IRCSS, Division of Cancer Prevention and Genetics, Milan, Italy. 5 Istituto Nazionale Tumori Fondazione G. Pascale IRCCS, Division of Radiation Oncology, Naples, Italy. 6 Istituto Nazionale Tumori Fondazione G. Pascale IRCCS, Epidemiology and Biostatistics Unit, Naples, Italy. 7 Istituto Nazionale Tumori Fondazione G. Pascale IRCCS, Unit of Rehabilitation Medicine, Naples, Italy. 8 Istituto Nazionale Tumori Fondazione G. Pascale IRCCS, Laboratory Medicine Unit, Naples, Italy. 9 European Institute of Oncology IRCSS, Division of Radiation Oncology, Milan, Italy

Purpose/Objective:

To report preliminary data from MICROSTYLE study, a clinical trial for prostate cancer (PCa) patients (pts) undergoing RT designed to investigate whether changes towards a healthy lifestyle are able to modify microbiome, improve quality of life and decrease the side effects of RT.

Material/Methods:

According to the study protocol 300 PCa pts undergoing adjuvant/salvage or curative RT will be recruited in two comprehensive Italian Cancer Centers. Participants will be randomized in two arms: Intervention Group (IG) and Control Group (CG); the ones allocated to the IG will receive personalized counseling on diet and exercise to improve overall lifestyle and to reduce eventual RT-related toxicities and a steps counter to monitor and increase physical activity reducing sedentary behavior. Participants included in the CG will receive baseline general advice and materials available for pts undergoing RT. The primary outcome will be assessed after 6 months by measuring the change in healthy lifestyle adherence (HLA) score between groups. The score is calculated according to the World Cancer Research Fund recommendations (2018). Each component is worth one point: 1, 0.5, and 0 points for fully, partially, and not meeting each recommendation, respectively. The score ranged from 0 to 7 points (minimal to