ESTRO 2024 - Abstract Book

S2535

Clinical - Urology

ESTRO 2024

Keywords: prostate, pelvic dose, sbrt

References:

1. van Dams, R., Jiang, N.Y., Fuller, D.B., Loblaw, A., Jiang, T., Katz, A.J., Collins, S.P., Aghdam, N., Suy, S., Stephans, K.L. and Yuan, Y., 2021. Stereotactic body radiotherapy for high-risk localized carcinoma of the prostate (SHARP) consortium: Analysis of 344 prospectively treated patients. International Journal of Radiation Oncology* Biology* Physics, 110(3), pp.731-737.

2469

Digital Poster

The influence of total dose on local control in renal cell cancer bone metastases

Fabian Lohaus 1,2,3 , Tobias Hölscher 1,2,3 , Esther Troost 1,4,3 , Mechthild Krause 1,5,3

1 Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Department of Radiotherapy and Radiation Oncology, Dresden, Germany. 2 National Center for Tumor Diseases (NCT), Partner Site Dresden, Dresden, Germany. 3 Helmholtz-Zentrum Dresden - Rossendorf, OncoRay - National Center for Radiation Research in Oncology, Dresden, Germany. 4 Helmholtz-Zentrum Dresden - Rossendorf, Institute of Radiooncology – OncoRay, Dresden, Germany. 5 German Cancer Consortium (DKTK), and German Cancer Research Center (DKFZ), Partner Site Dresden, Heidelberg, Germany

Purpose/Objective:

Metastases of renal cell carcinoma (RCC) are considered radioresistant. Even though, radiotherapy (RTx) is used in bone metastases of RCC for palliation of pain, for consolidation after stabilizing surgery, and in oligometastatic disease for local ablative RTx. Here, we report on the impact of RT dose on local control.

Material/Methods:

A retrospective analysis of all patients treated for bone metastases from RCC at our center between 2010 and 2020 is presented. Inclusion criteria were: Bone metastasis, minimum follow-up (FU) of 3 months, histologically confirmed RCC; exclusion criteria: neoadjuvant RTx, FU<3 months. The study endpoints were local control from the start of RTx and overall survival from the first fraction of RTx. Univariate and multivariate analyses (MVA) were performed using the Kaplan-Meier method and Cox regression.

Results: