ESTRO 2024 - Abstract Book

S2556

Clinical - Urology

ESTRO 2024

Two studies 18,23 investigated stress management interventions, one via the telephone and one via a tablet device. The telephone-based intervention also offered practical advice on side effect management. Neither intervention demonstrated a benefit in terms of sexual function or bother.

One study 19 examined a hybrid intervention involving psychological support combined with lifestyle, pelvic floor exercise and physical activity advice. There was no improvement in sexual function.

Exercise : Eight trials assessed a range of exercise interventions 9-16 . Six included resistance/aerobic exercise 10-14,16 , one focused on yoga 9 , and one involved a couples’ walking programme 15 . There was evidence of short-term improvement in sexual function in three studies 9,10,12 . One reported improvement in levels of sexual activity at 12 weeks 14 , while the ‘couples exercise’ programme showed an increase in partners' affectionate behaviour 13 . IADT : Seven trials 2-8 compared differences in sexual function and activity among men on continuous vs intermittent ADT, including several large multi-centre RCTs. The primary outcome measures for all the trials related to disease recurrence/progression and details of secondary sexual outcomes were often limited. The trials used a range of treatment schedules and were unblinded. All trials reported significant improvements in either sexual function or sexual activity among men in the IADT arm, although some data was incomplete. There was evidence of improved erectile function, improved libido and increased sexual activity when compared with men on continuous ADT. PDE5 inhibitors : One study 17 examined daily PDE5i use among men treated with RT±ADT. The primary endpoint demonstrated improvement in erectile function scores at 6 and 12 months. However sub-analysis showed those men whose treatment included ADT demonstrated no benefit at any timepoint.

Diet : One trial 1 investigated the benefits of daily consumption of soy protein in men with advanced PCa treated with ADT±RT. There was no significant improvement in libido or erectile function.