ESTRO 2024 - Abstract Book

S2627

Clinical - Urology

ESTRO 2024

Keywords: nomogram, salvage radiotherapy, machine learning

3165

Digital Poster

Profiling PCa patients with BCR: a multi-centric AIRO-URO group study

Giulia Marvaso 1,2 , Federico Mastroleo 1,3 , Riccardo Villa 1,4 , Mattia Zaffaroni 1 , Giulia Corrao 1 , Maria Giulia Vincini 1 , Fabio Montrone 5 , Alessandro Magli 6 , Giulio Francolini 7 , Ciro Franzese 8,9 , Luca Nicosia 10 , Francesco Pasqualetti 11 , Luca Trodella 12 , Annamaria Vinciguerra 13 , Salvina Barra 14 , Giorgia Timon 14 , Matteo Augugliaro 15 , Corrado Spatola 16 , Vincenzo Burgio 17 , Marta Scorsetti 8,9 , Stefano Arcangeli 18 , Luca Triggiani 19 , Barbara Alicja Jereczek-Fossa 1,4 1 IEO European Institute of Oncology IRCCS, Division of Radiation Oncology, Milan, Italy. 2 University of Piemonte Orientale, Department of Translational Medicine, Milan, Italy. 3 University of Piemonte Orientale, Department of Translational Medicine, Novara, Italy. 4 University of Milan, Department of Oncology and Hemato-Oncology, Milan, Italy. 5 Radiation Oncology Department, Centro di Riferimento Oncologico (CRO), Aviano, Italy. 6 Udine University Hospital, Department of Radiation Oncology, Udine, Italy. 7 Azienda Ospedaliero Universitaria Careggi, Radiation Oncology Unit, Florence, Italy. 8 IRCCS Humanitas Research Hospital, Department of Radiotherapy and Radiosurgery, Rozzano, Italy. 9 Humanitas University, Department of Biomedical Sciences, Pieve Emanuele, Italy. 10 IRCCS Sacro Cuore Don Calabria Hospital, Radiation Oncology Department, Negrar di Valpolicella, Italy. 11 Azienda Ospedaliero Universitaria Pisana, Radiation Oncology Unit, Pisa, Italy. 12 Campus Bio-Medico University, Department of Radiation Oncology, Rome, Italy. 13 SS. Annunziata Hospital, “G. D’Annunzio” University of Chieti, Radiation Oncology Unit, Chieti, Italy. 14 IRCCS Ospedale Policlinico San Martino, Department of Radiation Oncology, Genova, Italy. 15 Azienda USL-IRCCS, Radiation Oncology Unit, Reggio Emilia, Italy. 16 Policlinico di Catania, Division of Radiation Oncology, Catania, Italy. 17 Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Division of Radiation Oncology, Alessandria, Italy. 18 San Gerardo Hospital, Department of Radiation Oncology, Monza, Italy. 19 University and Spedali Civili Hospital, Radiation Oncology Department, Brescia, Italy

Purpose/Objective:

Although radical prostatectomy (RP) is a curative treatment, 44% of patients experience biochemical recurrence (BCR) at least 6 months after surgery. While the interval between surgery and BCR does not influence mortality in low-risk patients, those with unfavorable disease characteristics face an increased mortality risk with early disease recurrence. The aim of this study is to analyze a large retrospective multicenter cohort of patients who underwent salvage radiotherapy following BCR, to assess clinical outcomes and toxicities.

Material/Methods:

Data were acquired from 12 Italian centers participating in the AIRO-URO initiative. Patients who underwent radical prostatectomy (RP) and salvage radiotherapy (sRT) after experiencing biochemical recurrence (BCR) were