ESTRO 2024 - Abstract Book

S2874

Interdiscplinary - Other

ESTRO 2024

again this completely resolved post therapy. Only 1 patient died during the treatment after 3 fractions due to rapidly deteriorating respiratory function and was the only patient on oxygen at the start of the TLI.

FEV1 values were available for 12 patients immediately after TLI (n=10 at 3 months, n=7 at 6 months and n=6 at 12 months). The gradient of the slope for FEV1 was compared before and after TLI. The rate of decline improved from -0.41 L/month to -0.09 L/month during 0 – 3 months, from -0.77 L/month to +0.01 L/month during 0 – 6 months and from -0.65 L/month to -0.06 L/month during 0 – 12 months, before and after TLI. At the time of analysis 8/13 patients (61.5%) were still alive and the median survival post TLI was 17.4 months (range 0.2 to 36.5 months). One patient discussed above died during treatment and a second died 3.1 months after finishing due to a respiratory arrest. The cause of death could not be found for the remaining 3 patients. One patient was retransplanted 28.8 months following TLI.

Conclusion:

In appropriate patients with BOS post Lung Transplantation, TLI was generally well tolerated, with most complications clinically insignificant and the side effects transient. TLI was found to significantly slow down the rate of lung function decline (as other series have shown) even when the planned 8Gy in 10 fractions over 5 weeks radiotherapy course was not completed and should continue to be considered as an option for patients.

Keywords: total lymphoid irradiation, lung transplant

References:

1. Fisher, A.J., Rutherford, R.M., Bozzino, J., Parry, G., Dark, J.H. and Corris, P.A. (2005). The Safety and Efficacy of Total Lymphoid Irradiation in progressive Bronchioloitis Obliterans Syndrome After Lung Transplantation. Americal Journal of Transplantation, 5(3), 537-543.

111

Digital Poster

The status of Government-funded radiotherapy centres in Nigeria

SIMEON CHINEDU ARUAH

National Hospital Abuja, Radiotherapy and Oncology, Abuja, Nigeria. University of Abuja, Radiation Medicine, Abuja, Nigeria

Purpose/Objective:

Access to radiotherapy (RT) is now one of the stark examples of global cancer inequities. Over 800,000 new cancer cases require potentially curative or palliative RT services in Africa, arguably less than 15% of these patients currently have access to this important service. For a population of over 200 million, Nigeria requires a minimum of 280 RT machines for the increasing number of cancer cases. Painfully the country has only 8 government funded radiotherapy machines. This study aimed to evaluate the status of the eight (8) Government-funded RT