ESTRO 2024 - Abstract Book

S2911

Interdiscplinary - Other

ESTRO 2024

Results:

Beginning in April 2021, 28 patients have been enrolled in this still actively recruiting study. Two patients were excluded from analysis because of the detection of metastatic disease before the initiation of RT in one case and the refusal of the proposed treatment of another patient. Seventeen patients were male and eleven were female. Eighteen patients completed the RT treatment and ten were undergoing treatment at time of this preliminary analysis. No acute >G2 toxicities were observed. Three patients had to repeat the treatment planning CT scan (10,7%). These data compare favorably with the similar reference cohort of consecutive patients treated without interventions in 2019, when planning CTs had to be repeated in 42% of patients, which is similar to available literature data (41,5% reported by Murland et al.) (2). In our series the average number of CBCTs/MVCTs that exceeded the number of treatment fractions was only 2 (range 0-9): 7,1% patients had 1 CBCTs scan, 17,85% had 2 CBCT scans, 17,85% had 3 CBCTs scan, 3,6% had 4 CBCT scans and 3,6% had five or more CBCT scans in excess of fraction number (mean no. of CBCT/fraction: 1,07), an endpoint for which few literature data are available. When evaluating the same data for the 2019-cohort, the average number of CBCTs/MVCTs that exceeded the number of treatment fractions was 3 (range 0-23), 16,5% patients had 1 CBCT scans, 5,5 % had 2 CBCT scans, 8,7% had 3 CBCT scans, 11% had 4 CBCTs scan and 45% had five or more CBCT scans in excess of fraction number (mean no. of CBCT/fraction: 1,16).

Conclusion:

Personalized nutritional counselling may improve patient compliance to RT and intestinal preparation and thus reduce the number of IGRT-procedures during the course of RT especially compared with data related to our center in 2019 before the approval of the trial. Nutritional counselling may also reduce the number of CT replanning. Consequently, it might also reduce acute and late toxicities, with definitive results being available after full enrollment.

Keywords: nutritional counselling, replanning , pelvic RT

References:

1. Song Y, Ko WC, Tamas P, Hsu HY, Mueller BA, Braunstein LZ, et al. Effects of Bladder Filling and Rectal Gas on Number of CBCT Scans and Treatment Time for Prostate Cancer Patients Undergoing EBRT. International Journal of Radiation Oncology, Biology, Physics. 2021;111(3):e508. 2. Murland S, Paterson P, Poon W, Valiquette-Fleury S, Piva M. Improving Patient Preparation for Prostate Radiotherapy Simulation and Treatment- Is There Anything That Can Be Done? Journal of Medical Imaging and Radiation Sciences. 2020;51(3):S7.

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Image Fusion Using Pixelwise Gradient Model for Image Fusion (PGMIF)

Ka-Hei Cheng 1 , Wen Li 1 , Francis Kar-Ho Lee 2 , Tian Li 1 , Jing Cai 1