ESTRO 2024 - Abstract Book

S294

Brachytherapy - Head & neck, skin, eye

ESTRO 2024

Material/Methods:

Retrospective study of 50 patients with stage T1-T3N0 tongue and floor-of-mouth cancer who underwent tumour excision (+ elective neck dissection) followed by postoperative HDR-BT due to the presence of negative prognostic factors (close or positive resection margins, lymphovascular and/or perineural invasion, deep invasion). The plastic tube technique (dose: 18 x 3 Gy b.i.d.) was used. Survival outcomes, toxicity, and prognostic factors were evaluated.

Results:

At a median follow-up of 81 months (range, 4-121), actuarial 5-year local control (LC), nodal control (NC) and progression-free survival (PFS) rates were 79%, 69%, and 64%. After salvage treatment (surgery + external beam radiotherapy), LC, NC, and PFS increased to 87%, 77%, and 72.3%, respectively. Five-year overall survival and cancer-specific survival (CSS) rates were 73% and 77%. Treatment-related toxicity included two cases of mandibular osteoradionecrosis and five cases of small soft tissue necrosis. T stage was significantly correlated with nodal control (p=0.02) and CSS (p=0.04). Tumour grade correlated with DFS (p=0.01).

Conclusion:

Postoperative HDR-BT 18 x 3 Gy b.i.d. seems to be an effective method in patients with T1-3N0M0 oral cancer with negative prognostic factors after tumour resection.

Keywords: early oral cancer, postoperative treatment

855

Mini-Oral

Salvage HDR Interventional Radiotherapy (Brachytherapy) for Recurrent Head and Neck Cancers

Tamer Soror 1,2 , Justina Paul 3 , Corinna Melchert 1 , Christian Idel 3 , Dirk Rades 1 , Karl-Ludwig Bruchhage 3 , György Kovács 4 , Anke Leichtle 3 1 University of Lübeck/UKSH-CL, Radiation Oncology, Lübeck, Germany. 2 National Cancer Institute (NCI) , Cairo University, Radiation Oncology Department, Cairo, Egypt. 3 University of Lübeck/UKSH-CL, Department of Oto Rhino-Laryngology and Head and Neck Surgery, Lübeck, Germany. 4 Università Cattolica del Sacro Cuore, Gemelli INTERACTS, Rome, Italy

Purpose/Objective:

The management of locoregional recurrences of head-and-neck cancers after initial treatment is a major challenge for clinicians worldwide [1,2]. The rates of locoregional recurrences vary according to tumor location, stage, histology parameters, and applied primary treatment, ranging between 15–50% [1–5]. At our institute, we adapted an interdisciplinary salvage approach that combines surgery, whether radical or debulking, with HDR-IRT for