ESTRO 2024 - Abstract Book

S3210

Physics - Detectors, dose measurement and phantoms

ESTRO 2024

Conclusion:

The technical prerequisites of the SAPPHIRE project are fulfilled, a framework utilizing the SMART+ IB small animal imaging and irradiation device, designed for preclinical image-guided proton and photon comparison experiments at the UPTD. Beam models for photon and proton treatment were implemented and validated in µRayStation. Suitable setups and QA protocols for mouse imaging and irradiation were established. Hence, future preclinical animal experiments are prepared in a clinic-like workflow.

Keywords: small animal imaging & proton irradiation setup

References:

[1] Helmbrecht, S et al. (2016). “Design and implementation of a robust and cost-effective double-scattering system at a horizontal proton beamline”. In: Journal of Instrumentation 11.11, T11001.

[2] Schneider, Moritz et al. (2022). “Combined proton radiography and irradiation for high-precision preclinical studies in small animals”. In: Frontiers in Oncology 12. ISSN: 2234-943X.

[3] Tillner, Falk et al. (2016). “Precise image-guided irradiation of small animals: a flexible non-profit platform”. In: Physics in Medicine & Biology 61.8, p. 3084.

[4] Suckert, Theresa, Johannes Müller, et al. (2020). “High-precision image-guided proton irradiation of mouse brain sub-volumes”. In: Radiotherapy and Oncology 146, pp. 205–212.

[5] Suckert, Theresa, Elke Beyreuther, et al. (2021). “Late side effects in normal mouse brain tissue after proton irradiation”. In: Frontiers in Oncology 10, p. 598360.

[6] Suckert, Theresa, Treewut Rassamegevanon, et al. (2020). “Applying Tissue Slice Culture in Cancer Research - Insights from Preclinical Proton Radiotherapy”. In: Cancers 12.6, p. 1589.

[7] Müller, Johannes et al. (2020). “Multi-modality bedding platform for combined imaging and irradiation of mice”. In: Biomedical Physics & Engineering Express 6.3, p. 037003.

[8] Poirier, Yannick et al. (2020). “A failure modes and effects analysis quality management framework for image-guided small animal irradiators: A change in paradigm for radiation biology”. In: Medical physics 47.4, pp. 2013–2022.

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Digital Poster

Dose response and energy dependence of the new EBT4 GafChromic film model

Nada Tomic, Hamed Bekerat, Slobodan Devic