ESTRO 2024 - Abstract Book

S3326

Physics - Detectors, dose measurement and phantoms

ESTRO 2024

Conclusion:

This work presents an experimental platform for the investigation of the FLASH effect with drosophila melanogaster over a large range of dose rates. The main advantages compared to previous studies are the usage of an electron linac commonly available within radiotherapy departments and the adoption of an animal model with limited ethical restrictions and unsophisticated handling. Dose reporting for 16 MeV electron irradiations can be performed with a 5% accuracy and 1% (2.5%) precision for CONV (UHDR) irradiations. Finally, we report for the first time that a converted clinical linac can deliver up to 40 Gy/s photon megavoltage radiation for small animal experiments.

Keywords: FLASH, drosophila, 3D print

References:

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3. Su TT. What Drosophila Can Teach Us About Radiation Biology of Human Cancers. Adv Exp Med Biol. 2019;1167:225–36.