ESTRO 2024 - Abstract Book

S3554

Physics - Dose prediction, optimisation and applications of photon and electron planning

ESTRO 2024

Figure 1: Comparison of standard (top-left), isotoxic (middle-left) and dose difference (bottom-left) for an increase in prescription dose of 30Gy to 36Gy. Differences are shown through dose volume histogram (top-right) and line dose through isocentre (bottom-right). Standard represented with dashed-line and isotoxic solid-line.

Conclusion:

Isotoxic planning offers a personalised approach for re-irradiation, achieving higher PTV coverage without substantial increase in OAR dose. Overall, these results show that for the median increases in prescription dose (and therefore PTV D95%); the respective median increases in OAR D0.1cc are modest.

The study's findings demonstrate the feasibility of isotoxic radiotherapy in escalating dose to recurrent pelvic cancers in most cases.

Keywords: Isotoxic planning, re-irradiation, radiobiology

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Digital Poster

IOeRT conventional and FLASH TPS implementation exploiting fast GPU MonteCarlo: breast cancer case

Gaia franciosini 1,2 , Angelica De Gregorio 3,2 , Massimo Di Francesco 4 , Fabio Di Martino 5 , Giuseppe Felici 4 , Michela Marafini 6,2 , Annalisa Muscato 7,2 , Vincenzo Patera 1,2 , Philip Poortmans 8,9 , Angelo Schiavi 1 , Marco Toppi 1,2 , Giacomo Traini 2 , Antonio Trigilio 3,10 , Alessio Sarti 1,2