ESTRO 2024 - Abstract Book

S3599

Physics - Dose prediction, optimisation and applications of photon and electron planning

ESTRO 2024

Keywords: CBCT, HU calibration, radiotherapy planning

References:

1. Changsheng Ma et al., Radiotherapy dose calculation on KV cone-beam CT image for lung tumor using the CIRS calibration, Thoracic Cancer 5 (2014) 68–73,

2. D.Oborska-Kumaszynska, A new calibration method of an Elekta XVI (R.5.0.2) system able to achieve superior image quality, abstract book (conference paper, EP-1721), ESTRO 36 p. 5931.

3. D.Oborska-Kumaszynska, Calibration, and optimization of an XVI system (Elekta Synergy) - Pitfalls, Fizyk Inżynier Medyczny, nr 5/2016, vol.5, p. 274-280.

4. D.Oborska-Kumaszynska, D. Northover, Optymalizacja system XVI dla protokolow klinicznych (eng. Optimisation of a XVI system for clinical protocols), Fizyk Inżynier Medyczny 4 (2016), vol.5, p. 203-215.

5. SABR UK Consortium Guideline version 6.1, January 2019

6. ICRU Report 44: Tissue Substitutes in Radiation Dosimetry and Measurement, Volume os-23 Issue 1, January 1989.

1728

Poster Discussion

Development of a Preclinical X-ray Minibeam Monte Carlo Treatment Planning System using Topas

Stefano Pizzardi 1 , Lisa Alborghetti 1 , Claudio Fiorino 2 , Paolo Russo 3 , Giovanni Mettivier 3 , Antonella Del Vecchio 2 , Carlo Tacchetti 1 , Antonello Spinelli 1 1 IRCCS San Raffaele Scientific Institute, Experimental Imaging Centre, Milan, Italy. 2 IRCCS San Raffaele Scientific Institute, Medical Physics Department, Milan, Italy. 3 Università di Napoli Federico II, Dipartimento di Fisica, Napoli, Italy

Purpose/Objective:

Preclinical studies suggests that Minibeam Radiation Therapy (MBRT) is a promising approach to improve the therapeutic index by introducing high spatial dose modulation [1][2]. Unlike conventional radiotherapy (RT), which utilizes a broad beam to deliver a homogeneous dose distribution, in MBRT the radiation field is split into multiple narrow high dose regions (peaks) separated by low dose regions (valleys). The objective of this study is to present the development of a prototype of a preclinical treatment planning system (TPS) for X-ray MBRT using Monte Carlo (MC) simulations performed with Topas (Tool for Particle Simulation) [3][4]. By simulating the minibeam irradiation process, the aim is to investigate the relevant parameters, such as peak-