ESTRO 2024 - Abstract Book

S3642

Physics - Dose prediction, optimisation and applications of photon and electron planning

ESTRO 2024

Conclusion:

The robustness of DTRT and VMAT plans to the investigated US, however, depends on the direction of the uncertainty and relative location of the structure-of-interest with respect to the target. For structures above the VMAT beam-plane, particularly the hippocampus, the use of planning-at-risk volumes is recommended for DTRT. However, even in the presence of these uncertainties, DTRT demonstrated significantly lower predicted toxicity compared to VMAT over the investigated clinically motivated cases.

Supported by Varian, a Siemens Healthineers Company. The Monte Carlo dose calculations were performed on UBELIX (wwww.id.unibe.ch/hpc), the high-performance cluster at the University of Bern.

Keywords: VMAT, non-coplanar radiotherapy, robustness

References:

[1] Fix, M.K., Frei, D., Volken, W., Terribilini, D., Mueller, S., Elicin, O., Hemmatazad, H., Aebersold, D.M. and Manser, P. (2018), Part 1: Optimization and evaluation of dynamic trajectory radiotherapy. Med. Phys., 45: 4201-4212.

[2] Bertholet, J., Mackeprang, P-H., Mueller, S., Guyer, G., Loebner, H.A., Wyss, Y., Frei, D., Volken, W., Elicin, O., Aebersold, D.M., Fix, M.K. and Manser, P. (2022), Organ-at-risk sparing with dynamic trajectory radiotherapy for head and neck cancer: comparison with volumetric arc therapy on a publicly available library of cases. Radiat Oncol 17, 122.