ESTRO 2024 - Abstract Book

S3668

Physics - Dose prediction, optimisation and applications of photon and electron planning

ESTRO 2024

Regions exhibiting statistically significant dose differences have a red background. We observed enhanced SRS sparing while, simultaneously, the DVH for OARs showed improvement for the entire bladder and rectum. Furthermore, the complexity of plans did not increase with gEUD optimization (median ΔMU = - 0.2).

Conclusion:

MCO offers the possibility to selectively spare vesical and rectal substructures associated with symptoms while maintaining adequate target coverage. Incorporating gEUD as an optimization objective is particularly effective in regulating the high-dose portion of the DVH, especially for the SBR. We are currently using the resulting KB+gEUD plans to develop an initial version of a new KB model, enabling automated dose optimization for subregions linked to toxicity.

Keywords: prostate, toxicity, multi-criteria optimization

References:

This work has been supported by Fondazione Regionale per la Ricerca Biomedica, project nr. 110 - JTC PerPlanRT ERA PerMed, GA 779282

[1] Alborghetti L, Castriconi R, Sosa Marrero C, Tudda A, Ubeira-Gabellini MG, Broggi S, et al. Selective sparing of bladder and rectum sub-regions in radiotherapy of prostate cancer combining knowledge-based automatic planning and multicriteria optimization. Phys Imaging Radiat Oncol 2023;28:100488. https://doi.org/10.1016/j.phro.2023.100488.

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