ESTRO 2024 - Abstract Book

S3685

Physics - Dose prediction, optimisation and applications of photon and electron planning

ESTRO 2024

A moderate correlation occurred between the gain of the area under OVH curves, and the OAR mean dose gain, for the OVHopt and the OVHunopt plans (Figure 1B.), with a R 2 of 0.74. Based on these results, we confirmed that OVHs could give insights on OAR mean dose spare starting from only the vertex placement even for LRT dose distributions. Figure 2 shows an example of the difference between vertex spatial distribution with and without the OVH optimization; Hausdorff distance minimization allows to reach a uniform vertex distribution when no OARs are selected.

Conclusion:

We implemented an automatic tool (LatticeOpt) that generates optimal lattice arrangements, and we validated it on real anatomy cases. The results showed that the tool was able to find optimized lattice structures as solutions in terms of both spatial disposition and OARs sparing. Our framework could reduce most of the time-consuming procedures of LRT, as well as achieve standardized and reproducible results, paving the way for multicentric studies.

Keywords: Lattice radiotherapy, Optimization, SFRT

References:

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