ESTRO 2024 - Abstract Book

S3829

Physics - Image acquisition and processing

ESTRO 2024

Figure 2: Notched box plots of OE-MRI derived estimates of malignant tissue hypoxic fractions. Black boxes around the primary tumour hypoxic fraction estimates indicate radio-resistant tumours. Red lines indicates median values.

Conclusion:

It is possible to perform volumetric OE-MRI in patients with HNSCC using routinely available equipment in an acute hospital setting prior to definitive radiotherapy treatment. In this pilot study, OE-MRI derived estimates of primary tumour hypoxic fractions show a statistically non-significant trend towards greater values in radio-resistant tumours. No such trend was observed with volume averaged ΔT 1 times. Further multicentre studies are warranted to investigate OE-MRI as a predictor of hypoxia induced radio-resistance in HNSCC and to guide the selection of patients more likely to benefit from hypoxia modification treatment techniques.

This work is funded by a grant from Nottingham Hospitals Charity (APP2361/N0379).

Keywords: Tumour hypoxia, Oxygen-enhanced MRI, head and neck

References:

1. Brizel DM, Dodge RK, Clough RW, Dewhirst MW (1999) Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome. Radiother Oncol 53:113–117