ESTRO 2024 - Abstract Book

S3910

Physics - Image acquisition and processing

ESTRO 2024

Figure 1: Histogram with myelin concentration in corpus callosum.

Since the whole brain comparisons could be affected by surgery, further investigation of the CC was made. The CC also had less myelin, with a greater loss for irradiated brain tumor patients. In Figure 1 it is observed that for irradiated brain tumor patients there is a decrease of high concentrations of myelin (showed in orange) as well as a higher amount of low concentration myelin. For smaller CC, there were more partial volume effects during segmentation, this was partially compensated for by drawing in several slices. However, the partial volume can cause some of the increase, observed in the low concentration area.

Conclusion:

Effects on the CC, originating from brain tumor irradiation, can be analyzed using qMRI. These effects have earlier been demonstrated using other MR-techniques such as DWI, but it is now shown that relaxometry is useful for evaluating such effects in children treated for brain tumors.

In the future we will expand the study to include more patients, but also to compare with other new techniques such as advanced diffusion measurements with q-space trajectory imaging (QTI)(5).

Keywords: Magnetic resonance imaging, myelin, brain tumor

References:

1. Kvernby S, Warntjes MJB, Haraldsson H, Carlhäll C-J, Engval J, Ebbers T. Simultaneous three-dimensional myocardial T1 and T2 mapping in one breath hold with 3D-QALAS. Journal of Cardiovascular Magnetic Resonance (BioMed Central). 2014;16:1-14.