ESTRO 2024 - Abstract Book

S4002

Physics - Inter-fraction motion management and offline adaptive radiotherapy

ESTRO 2024

4. Stranzl, H. & Zurl, B. Postoperative irradiation of left-sided breast cancer patients and cardiac toxicity. Does deep inspiration breath-hold (DIBH) technique protect the heart? Strahlenther. Onkol. Organ Dtsch. Rontgengesellschaft Al 184, 354–358 (2008). 5. Vikström, J., Hjelstuen, M. H. B., Mjaaland, I. & Dybvik, K. I. Cardiac and pulmonary dose reduction for tangentially irradiated breast cancer, utilizing deep inspiration breath-hold with audio-visual guidance, without compromising target coverage. Acta Oncol. Stockh. Swed. 50, 42–50 (2011). 6. Johansen, S. et al. Dose evaluation and risk estimation for secondary cancer in contralateral breast and a study of correlation between thorax shape and dose to organs at risk following tangentially breast irradiation during deep inspiration breath-hold and free breathing. Acta Oncol. Stockh. Swed. 50, 563–568 (2011). 7. McIntosh, A., Shoushtari, A. N., Benedict, S. H., Read, P. W. & Wijesooriya, K. Quantifying the reproducibility of heart position during treatment and corresponding delivered heart dose in voluntary deep inhalation breath hold for left breast cancer patients treated with external beam radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 81, e569-576 (2011). 8. Alderliesten, T. et al. Accuracy evaluation of a 3-dimensional surface imaging system for guidance in deep inspiration breath-hold radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 85, 536–542 (2013). 9. Tang, X. et al. Clinical experience with 3-dimensional surface matching-based deep inspiration breath hold for left-sided breast cancer radiation therapy. Pract. Radiat. Oncol. 4, e151–e158 (2014). 10. Tang, X. et al. Dosimetric effect due to the motion during deep inspiration breath hold for left ‐ sided breast cancer radiotherapy. J. Appl. Clin. Med. Phys. 16, 91–99 (2015). 11. Reitz, D. et al. Stability and reproducibility of 6013 deep inspiration breath-holds in left-sided breast cancer. Radiat. Oncol. Lond. Engl. 15, 121 (2020). 12. Chapman, C. H. et al. Mediators of Racial Disparities in Heart Dose Among Whole Breast Radiotherapy Patients. J. Natl. Cancer Inst. 114, 1646–1655 (2022). 13. He, K., Gkioxari, G., Dollár, P. & Girshick, R. Mask R-CNN. Preprint at https://doi.org/10.48550/arXiv.1703.06870 (2018). 14. Keall, P. J. et al. AAPM Task Group 264: The safe clinical implementation of MLC tracking in radiotherapy. Med. Phys. 48, e44–e64 (2021).

934

Digital Poster

A comparative analysis of expiration gating and free breathing in pancreatic cancer radiotherapy

Brigit CM Mientjes 1 , Eva Versteijne 1 , Isabel F Remmerts de Vries 1 , Anna ME Bruynzeel 1 , Wilko FAR Verbakel 1,2 , Tezontl S Rosario 1

1 AmsterdamUMC, Radiation oncology, Amsterdam, Netherlands. 2 Varian Medical Systems, Research, Palo Alto, USA

Purpose/Objective:

Neoadjuvant chemoradiotherapy is standard treatment for patients with borderline resectable pancreatic cancer in the Netherlands [1]. In the Amsterdam UMC, patients received liquid bioX markers intratumoral, followed by a 4D planning CT to for account breathing motion of the tumor. For the free breathing strategy (FB), the GTV is delineated in all respiratory phases, resulting in large planning target volumes (PTV), which may lead to a higher chance of acute