ESTRO 2024 - Abstract Book

S4139

Physics - Intra-fraction motion management and real-time adaptive radiotherapy

ESTRO 2024

Conclusion:

The new concept of PGI-triggered partial adaptation turned out to compensate for the dosimetric influence of anatomical changes similarly well as full adaptation, especially in terms of restoring target coverage for patients treated with only two-field plans. It could therefore be applied in near real-time OAPT triggered by in vivo treatment verification (e.g., by PGI) after the first non-adapted field delivery. Moreover, such a workflow would offer the opportunity to adapt the plan only if a relevant treatment deviation is actually detected, thus reducing the daily burden when there is no need for adaptation. Finally, online adaptation triggered by in vivo treatment verification would enable the implementation of a closed OAPT feedback loop.

Keywords: Online-adaptive PT, Partial plan adaptation, PGI

References:

[1] Berthold, J. et al., (2023). Detectability of Anatomical Changes With Prompt-Gamma Imaging: First Systematic Evaluation of Clinical Application During Prostate-Cancer Proton Therapy. International Journal of Radiation Oncology*Biology*Physics, 117(3), 718–729. https://doi.org/10.1016/j.ijrobp.2023.05.002