ESTRO 2024 - Abstract Book

S4149

Physics - Intra-fraction motion management and real-time adaptive radiotherapy

ESTRO 2024

validation for intrafraction adaptations using CMM for prostate cancer patients on the 1.5T MR-linac. Future work will focus on the introduction of a T2-weighted 2D cine MRI sequence in order to improve image contrast and thereby ease visual assessment of the accuracy of motion measurements.

Keywords: adaptive radiotherapy, intrafraction motion

References:

[1]: Real ‐ time motion monitoring using orthogonal cine MRI during MR ‐ guided adaptive radiation therapy for abdominal tumors on 1.5T MR ‐ Linac, Jassar et al 2023, Medical Physics

[2]: Feasibility of real ‐ time motion tracking using cine MRI during MR ‐ guided radiation therapy for abdominal targets, Keiper et al 2020, Medical Physics

[3]: Clinical application of a sub-fractionation workflow for intrafraction re-planning during prostate radiotherapy treatment on a 1.5 Tesla MR-Linac: A practical method to mitigate intrafraction motion, Willigenburg et al 2022, Radiotherapy and Oncology

[4]: S. Klein, M. Staring, K. Murphy, M.A. Viergever, J.P.W. Pluim, "elastix: a toolbox for intensity based medical image registration," IEEE Transactions on Medical Imaging, vol. 29, no. 1, pp. 196 - 205, January 2010.

188

Digital Poster

Evaluation of Cardiac Motion for PMRT patients with IMNIs using CT with Coronary Angiography

Zhe Zhang 1 , Zhaohui Tang 1 , Zhibo Tan 1 , Feng Peng 1 , Lei Zhang 1 , Zhaoming Peng 1 , Xin Li 1 , Pengfei Yang 1 , Ling Liu 1 , Jin Wang 2 , Damin Li 3 , Yuenan Wang 4 , Yajie Liu 5,1 1 Peking University ShenZhen Hospital, Radiation Oncology, ShenZhen, China. 2 Southern University of Science and Technology, School of medicine, ShenZhen, China. 3 Affiliated Nanhua Hospital university of South China, Oncology, HengYang, China. 4 Yale University School of Medicine, Department of Therapeutic Radiology, New Heaven, USA. 5 Shenzhen-Peking University, Hong Kong University of Science and Technology Medical Center, ShenZhen, China

Purpose/Objective:

There is much evidence that cardiac substructures are highly sensitive to radiation, and it is becoming increasingly important to accurately assess the dose to the heart. Especially for breast cancer patients with Postmastectomy Radiotherapy (PMRT) of Internal Lymph Mammary node irradiation (IMNIs), it also plays a vital role in ensuring the patient's quality of life in the long term. However, due to the fact that these structures are not easily observed on treatment planning CT (TPCT) and are accompanied by a beating heart, dose calculations for the heart using only TPCT are not accurate. This work uses Coronary Computed Tomography Angiography (CCTA) for cardiac cycle