ESTRO 2024 - Abstract Book

S4204

Physics - Intra-fraction motion management and real-time adaptive radiotherapy

ESTRO 2024

1. D. A. Low, P. J. Parikh, W. Lu, J. F. Dempsey, S. H. Wahab, J. P. Hubenschmidt, M. M. Nystrom, M. Handoko, and J. D. Bradley, A novel breathing motion model for radiation therapy, Int. J. Radiat. Oncol. Biol. Phys. 63, 921-929 (2005).

2. D. Low, B. White, P. Lee, D. Thomas, S. Gaudio, S. Jani, X. Wu, and J. Lamb, A novel CT acquisition and analysis technique for breathing motion modeling, Phys. Med. and Biol. 58, L31-L36 (2013).

3. D. Thomas, J. Lamb, B. White, S. Jani, S. Gaudio, P. Lee, D. Ruan, M. McNitt-Gray, and D. Low, A novel fast-helical 4D CT acquisition technique to generate low noise artifact-free images at user selected breathing phases, Int. J. Radiat. Oncol., Biol., Phys. 89 191-198 (2014).

4.T. Dou, D. Thomas, D. O’Connell, J. Lamb, P. Lee, and D. Low, A method for assessing ground-truth accuracy of the 5DCT technique, Int. J. Radiat. Oncol. Biol. Phys, 93, 925-933 (2015).

918

Digital Poster

Evaluating prompt gamma ray timing for proton therapy verification under quasi-clinical irradiations

Krystsina Makarevich 1,2 , Toni Koegler 1,2 , Sonja M. Schellhammer 1,2,3 , Aaron Kieslich 1,2 , Katja E. Roemer 4 , Joseph A. B. Turko 4 , Konstantin Urban 1,2 , Andreas Wagner 4 1 Dresden University of Technology, Helmholtz-Zentrum Dresden-Rossendorf, OncoRay – National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden, Germany. 2 Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiooncology – OncoRay, Dresden, Germany. 3 Hochschule Zittau/Goerlitz – University of Applied Sciences, Faculty of Natural and Environmental Sciences, Zittau, Germany. 4 Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiation Physics, Dresden, Germany

Purpose/Objective:

Prompt gamma ray timing (PGT) is an in-vivo proton range verification method that has the potential to be used in real-time adaptive proton therapy. This is because time distributions of produced prompt gamma rays (PGs) comprise the information about the proton range [1]-[4], and the promptness of the PG emission and its subsequent detection allows online treatment verification. The PGT system is currently undergoing extensive testing under conditions simulating treatments for brain cancer to determine its potential for detecting range deviations in proton therapy.

Material/Methods:

An anthropomorphic head phantom from CIRS® (see Figure 1) was irradiated with relevant clinical treatment plans at the OncoRay's pencil beam scanning beamline. These plans describe 8×8 cm 2 irradiation fields of distinct energies. Each field comprises spots with regularized coordinates, but whose intensities are consistent with the values extracted from real glioblastoma treatment plans. The time distributions of produced PGs were measured relatively to the cyclotron radio frequency with eight CeBr 3 scintillation detectors. To suppress the impact of PGs originating in the range compensator (RC), all detectors were placed inside small-size lead collimators. Fast plug-on spectrometers