ESTRO 2024 - Abstract Book

S4228

Physics - Intra-fraction motion management and real-time adaptive radiotherapy

ESTRO 2024

Keywords: intra-fractional motion, upper abdomen, PRV margin

References:

1. Impact of planning organ at risk volume margins and matching method on late gastrointestinal toxicity in moderately hypofractionated IMRT for locally advanced pancreatic ductal adenocarcinoma. Radiat Oncol. 2023 Jun 19;18(1):103.

1080

Proffered Paper

The first clinical implementation of real-time 6DoF tumour tracking for liver SABR in the LARK trial

Chandrima Sengupta 1 , Doan T Nguyen 1,2 , Trevor Moodie 3 , Benjamin Zwan 4 , Sau Fan Liu 5 , Daniel Mason 6 , Trent Causer 6 , Jianjie Luo 6 , Nicholas Hardcastle 7 , Lauren Inskip 3 , Rebecca Cone 4 , Benjamin Tacon 4 , Elizabeth Brown 5 , Maegan Stewart 8 , Sankar Arumugam 9 , Tim Wang 3 , Simon Tang 4 , Yoo Young Lee 5 , Kirsten van Gysen 6 , Julie Chu 7 , Yifan Li 1 , Peter Greer 10 , Jeremy Booth 8 , Ricky O'Brien 11,1 , Paul Keall 1,2 1 Image X Institute, The University of Sydney, School of Health Sciences, Sydney, Australia. 2 SeeTreat Medical, Engineering and development, Sydney, Australia. 3 Crown Princess Mary Cancer Centre, Department of Radiation Oncology, Sydney, Australia. 4 Central Coast Cancer Centre, Gosford Hospital, Department of Radiation Oncology, Gosford, Australia. 5 Princess Alexandra Hospital, Department of Radiation Oncology, Brisbane, Australia. 6 Nepean Cancer & Wellness Centre, Department of Radiation Oncology, Nepean, Australia. 7 Peter MacCallum Cancer Centre, Department of Radiation Oncology, Melbourne, Australia. 8 Royal North Shore Hospital, Department of Radiation Oncology, Sydney, Australia. 9 Liverpool and Macarthur Cancer Therapy Centres, Department of Radiation Oncology, Liverpool, Australia. 10 Calvary Mater Newcastle, Department of Radiation Oncology, Newcastle, Australia. 11 RMIT University, School of Health and Biomedical Sciences, Melbourne, Australia

Purpose/Objective:

Liver cancer SABR remains one of the most challenging treatments to implement due to the dynamic nature of the liver. Multiple survey results have identified a demand for improved motion management in liver SABR 1,2 . These surveys show that to grow the use of, and confidence in, liver cancer SABR, an available, easy-to-implement real-time tumour motion monitoring technique is needed. Until now, real-time IGRT for liver has been the domain of dedicated and expensive cancer radiotherapy systems 3,4,5 . The purpose of this study was to clinically implement a novel real time 6 degree-of-freedom (DoF) IGRT system, Kilovoltage Intrafraction Monitoring (KIM) 6,7 for liver SABR patients in the multi-institutional TROG 17.03 LARK clinical trial 8 . Here we report on the first in-human prospective use of KIM for 28 liver SABR patients in the LARK clinical trial.

Material/Methods: