ESTRO 2024 - Abstract Book

S4263

Physics - Intra-fraction motion management and real-time adaptive radiotherapy

ESTRO 2024

Table 1. Comparison of dose to organs at risk (mean, [min, max]) between ITV-based and MidP based plans

Organ at risk

DVH parameter

ITV

MidP

p-value

Heart

D50%

3.9, [0.8, 5.3]

3.7, [0.1, 5.0]

<0.001

Coronary arteries D1%

18.6, [6.5, 21.1]

18.3, [6.0, 20.6]

0.019

Stomach

D1%

8.3, [0.2, 22.4]

6.8, [0.2, 21.0]

0.016

Aorta

D1%

9.9, [2.0, 19.6]

9.0, [1.7, 16.9]

0.026

Lungs

D5%

7.7, [2.5, 12.7]

6.8, [1.6, 11.2]

<0.001

D50%

0.7, [0.1, 1.5]

0.6, [0.1, 1.3]

0.007

Conclusion:

Compared to ITV based approach, the use of mid-position strategy for treatment planning of stereotactic arrhythmia radioablation leads to significantly smaller PTV and lower surrounding OAR doses while still achieving a clinically acceptable CTV coverage.

Keywords: Mid-position,Stereotactic Arrhythmia Radioablation

References:

[1] J. Bellec et al., “Cardiac radioablation for ventricular tachycardia: Which approach for incorporating cardiorespiratory motions into the planning target volume?,” Phys. Med., vol. 95, pp. 16–24, Mar. 2022, doi: 10.1016/j.ejmp.2022.01.004. [2] O. Blanck et al., “Radiosurgery for ventricular tachycardia: preclinical and clinical evidence and study design for a German multi-center multi-platform feasibility trial (RAVENTA),” Clin. Res. Cardiol., vol. 109, no. 11, pp. 1319–1332, Nov. 2020, doi: 10.1007/s00392-020-01650-9.