ESTRO 2024 - Abstract Book

S4401

Physics - Intra-fraction motion management and real-time adaptive radiotherapy

ESTRO 2024

Keywords: MR-guided Radiotherapy, Clinical Trial

References:

1. Paikh PJ, Lee P, Low DA, et al. A Multi-Institutional Phase 2 trial of Ablative 5-Fraction Stereotactic Magnetic Resonance-Guided On-Table Adaptive Radiation Therapy for Borderline Resectable and Locally Advanced Pancreatic Cancer. Int J Radiat Oncol Biol Phys. 2023; 117(4):799-808.

2. Reyngold M, Parikh P, Crane CH. Ablative radiation therapy for locally advanced pancreatic cancer: techniques and results. Radiat Oncol. 2019;14(1):95.

3. Chuong MD, Bryant J, Mittauer KE, et al. Ablative 5-Fraction Stereotactic Magnetic Resonance-Guided Radiation Therapy With On-Table Adaptive Replanning and Elective Nodal Irradiation for Inoperable Pancreas Caner. Pract Radiat Oncol. 2021; 11(2):134-147

3177

Mini-Oral

Non-invasive motion tracking in radiotherapy of lung cancer via transfer learning networks

Jie Wei 1 , Jun Deng 2 , Ming Chao 3

1 City College of New York, Department of Computer Science, New York, USA. 2 Yale University, Department of Therapeutic Radiology, New Haven, USA. 3 Icahn School of Medicine at Mount Sinai, Department of Radiation Oncology, New York, USA

Purpose/Objective:

Non-invasive lung tumor motion tracking on the sequential kilovoltage (kV) X-ray images acquired during treatment can facilitate accurate delivery of stereotactic body radiation therapy treatment for lung cancer. Yet, it requires reliable identification of the tumor target on these extremely low contrast and noisy X-ray images. The goal of this study is to develop a transfer learning deep segmentation net jury committee (TL-DSN-JC) algorithm to extract the lung tumor targets on these images for more accurate motion tracking in the radiotherapeutic management of lung cancer.

Material/Methods:

600 radiographic images from 71 early stage non-small-cell lung cancer (NSCLC) patients treated with stereotactic body radiation therapy (SBRT) were retrospectively selected in the study. The images were acquired as the kV setup orthogonal images using the on-board imager mounted on the Varian 21iX Clinac (Varian Medical Systems, Palo Alto, CA).