ESTRO 2024 - Abstract Book

S447

Clinical - Breast

ESTRO 2024

25

Digital Poster

Multi-component intervention on radiotherapy induced fatigue in Breast cancer patients:A Pilot trial

Blessy Mohandass 1,2 , Narendra Kumar Bhalla 2 , Smita Singh 1

1 Chitkara University, Chitkara School of Health Sciences, Rajpura, India. 2 Fortis Hospital, Department of Radiation Oncology, Mohali, India

Purpose/Objective:

Cancer breast is the second most frequent type of cancer and the primary cause of cancer death among women. Patients undergoing treatment experience treatment-related side effects that impair activities of daily living and negatively affect the quality of life. The purpose of this study was to evaluate the effectiveness of a multi component intervention (MCI) on radiotherapy induced fatigue and its corelates among breast cancer patients.

Material/Methods:

A Randomized Controlled Pilot Trial was conducted at a single medical center. 16 Female patients scheduled for radiation therapy (RT) post breast conservation surgery (BCS) were randomly allocated to either interventional (n=8) or control group (n=8). A multicomponent intervention, comprising of guided imagery, an information booklet on managing side effects with diet and thrice a week SMS reminder was given to MCI group, from the first day till last day of RT, control group received routine care. Primary outcome measure was Cancer Fatigue Scale (CFS) for fatigue levels. Secondary measures for corelates of fatigue: Zung Self Rating Depression Scale (ZSDS), Zung Self Rating Anxiety Scale (ZSAS), Pittsburgh Sleep Quality Index (PSQI) and Scored Patient-Generated Subjective Global Assessment (PG-SGA) were measured before (pre-test), at mid (post-test I) and at end of RT (post-test II).

Results:

The study sample had a mean age 54.66± 1.63. There was no mean difference in the fatigue scores (CFS), depression level (ZSDS), anxiety level (ZSAS), sleep quality (PQSI), PG-SGA Global Assessment Scores (PGSGA) between the groups before RT at pre-test. MCI reduced fatigue levels in interventional group significantly at post test I (CFS 44.625 ± 3.020) and post-test II (35.25 ± 2.492) compared with control (CFS 54.37 ± 3.248; 56.37 ± 2.503), p = < 0.05 and p = < 0.05, respectively. Depression (ZSDS) levels at pre-test (59.38 ± 7.328) decreased in interventional group at post-test I (ZSDS 55.13 ± 0.120) and post-test II (ZSDS 46.25 ± 1.909) compared to control with pre-test score (ZSDS 64.88 ± 2.949), post-test I (ZSDS 62.633 ± 3.378) and post-test II (ZSDS 62.633 ± 3.378). Same pattern was seen in case of anxiety levels. Sleep quality (PSQI) (PSQI 12.38 ± 4.207) in interventional group remained same at post-test I (PSQI 12.38 ± 4.207) but improved by end of RT (PSQI 8.88 ± 4.155), as compared to control Pre-Test (PSQI 13.25 ± 3.694), Post-Test I (PSQI 13.25 ± 2.375) & Post Test II (PQSI 14.38 ± 2.264) which remained poor. Nutritional status (PGSGA) of the patient remained the same in both the groups at both post-test assessments.

Conclusion: