ESTRO 2024 - Abstract Book

S4636

Physics - Optimisation, algorithms and applications for ion beam treatment planning

ESTR0 2024

Conclusion:

All plans and OARS constraints were easily met using VMAT, CK and PBT for our small RCC cases. OAR doses between VMAT and CK are similar and unlikely to result in any clinically significant differences. VMAT is a fast treatment, is widely available and is a transferable technology across many cancer institutions. There was a trend towards lower OAR doses with PBT across most OARs; higher skin doses were seen but these were still within acceptable skin constraints. PBT may offer greater nephron sparing and may be indicated in cases of poor baseline renal function. Low bowel doses with PBT may help to reduce nausea from treatment. It may also be considered in patients with an underlying condition where further bowel sparing may be particularly important e.g. inflammatory bowel disease. Further prospective work is required to investigate particle therapy in RCC. There is a move towards single fraction treatments in small RCCs, hence effective motion management mitigation strategies will be particularly important with particle therapy treatments. Further work is ongoing to optimise these.

Acknowledgements: NIHR RMH Biomedical Research Centre

Keywords: Renal Cell Carcinoma, photon, proton beam

References:

1. Siva, S., et al., 5-year outcomes after stereotactic ablative body radiotherapy for primary renal cell carcinoma: an individual patient data meta-analysis from IROCK (the International Radiosurgery Consortium of the Kidney). Lancet Oncol, 2022. 23(12): p. 1508-1516.

2. Correa, R.J.M., et al., The Emerging Role of Stereotactic Ablative Radiotherapy for Primary Renal Cell Carcinoma: A Systematic Review and Meta-Analysis. Eur Urol Focus, 2019. 5(6): p. 958-969.

3. Siva, S., et al., Impact of stereotactic radiotherapy on kidney function in primary renal cell carcinoma: Establishing a dose–response relationship. Radiotherapy and Oncology, 2016. 118(3): p. 540-546.

4. Berghen, C., et al., The role of radiation therapy and particle therapy in renal cell carcinoma: current evidence and future perspectives. Journal of Cancer Metastasis and Treatment, 2021.

5. Ishikawa, H., et al., A Japanese registry study and systematic review of particle therapy for renal cell carcinoma. J Radiat Res, 2023. 64(Supplement_1): p. i41-i48.

1533

Mini-Oral

New cyclotron-based proton therapy facility development to achieve conformal FLASH treatment plans

Vivek Maradia 1,2 , Steven van de Water 3 , Damien Charles Weber 1,4,5 , Antony John Lomax 1,2