ESTRO 2024 - Abstract Book

S4638

Physics - Optimisation, algorithms and applications for ion beam treatment planning

ESTR0 2024

1925 Gy/s for Lung (PTV: 1300 cm^3), and 1552 Gy/s for Nasal Cavity (PTV: 246 cm^3) tumors, even with fraction doses of 2 Gy.

Furthermore, we've attained a minimum Average Dose Rate (ADR) per field of 13 Gy/s for Liver, 9 Gy/s for Lung, and 24 Gy/s for Nasal Cavity cases with 6 Gy per fraction.

Conclusion:

Our innovative beamline design, incorporating momentum cooling, alongside the utilization of patient-specific ridge filter designs tailored to the highest energy required for coverage and spot-reduced planning, empowers us to attain precise dose distribution while achieving conformal Flash dose rates and minimizing neutron exposure to patients. Furthermore, the Dose Average Dose Rate (DADR) per field remains constant regardless of the dose administered per fraction. However, the Average Dose Rate (ADR) will rise as the dose per fraction increases.

Keywords: Flash, Ridge filter, Proton therapy

References:

[1] Maradia, V., Meer, D., Dölling, R. et al. Demonstration of momentum cooling to enhance the potential of cancer treatment with proton therapy. Nat. Phys. 19, 1437–1444 (2023). https://doi.org/10.1038/s41567-023-02115-2

[2] Maradia, V. et al. Ultra-fast pencil beam scanning proton therapy for locally advanced non-small-cell lung cancers: field delivery within a single breath-hold. Radiother. Oncol.174, 23–29 (2022).