ESTRO 2024 - Abstract Book

S4644

Physics - Optimisation, algorithms and applications for ion beam treatment planning

ESTR0 2024

Conclusion:

A comprehensive IGRT workflow for partial brain irradiation in healthy mice including non-invasive response assessment was developed and successfully tested in vivo. UHF µMRI has a large potential for longitudinal studies in a pre-clinical research setting, but geometrical distortions from various sources need to be accounted for by shimming optimization and non-rigid MR to CT registration. For voxel-based analysis a resolution of 0.2 mm is feasible. To further improve the positioning accuracy the integration of liquid fiducials markers (BioXmark, Nanovi) and kV-based in-room imaging is envisaged, finally to be tested in an end-to-end test employing a mouse phantom 2 . Current work aims at the voxel-wise correlation of MR images with dose and LET d values.

Keywords: pre-clinical research, MRI response-assessment

References:

1 Knäusl et al PhysMed (2023) doi: 10.1016/j.ejmp.2023.102659

2 Wegner et al PhysMedBiol (2023) doi: 10.1088/1361-6560/acc566

1626

Digital Poster

A deterministic dose engine for preclinical proton dose calculations

Justin Malimban 1 , Tiberiu Burlacu 2 , Zoltán Perkó 2 , Sytze Brandenburg 1 , Danny Lathouwers 2

1 University Medical Center, Department of Radiation Oncology, Groningen, Netherlands. 2 Delft University of Technology, Department of Radiation Science and Technology, Delft, Netherlands

Purpose/Objective: