ESTRO 2024 - Abstract Book

S4651

Physics - Optimisation, algorithms and applications for ion beam treatment planning

ESTR0 2024

Figure 1: Example of the difference between manual and automated planning: A: Manually created plan, B: Automatically generated plan, C: Dose Difference A-B: The colors pink, red and orange indicate a higher dose in A, while the colors blue and purple indicate a lower dose in A compared to B.

Figure 2: Comparison between automated and manual plans of ACE, MLD and MBD. A higher value for the ∆NTCP for ACE indicates a larger difference between the proton and photon plan, and therefore a better performance of the method for plan generation.

Conclusion:

We have successfully implemented automatic IMPT treatment planning in clinical practice for plan comparison for breast cancer patients, achieving a time-save of 1 hour per plan. While plan quality is maintained, we recommend a manual review to detect potential inaccuracies, particularly when the NTCP gain is near the threshold for referral.

Keywords: Proton therapy, automated planning,

References:

[1]

NVRO.

Landelijk

Indicatie

Protocol

Protonen

Therapie

Borstkanker,

Available

from:

https://nvro.nl/publicaties/rapporten, Versie 2, 21 februari 2022.

[2] Taasti VT, Hong L, Deasy JO, Zarepisheh M. Automated proton treatment planning with robust optimization using constrained hierarchical optimization. Med Phys. 2020 Jul 1;47(7):2779–90.