ESTRO 2024 - Abstract Book

S4656

Physics - Optimisation, algorithms and applications for ion beam treatment planning

ESTR0 2024

Conclusion:

This study demonstrated that proton therapy DP with 4 beams could be used to improve GTV coverage with a higher dose of radiation, potentially leading to improved chances of local control with respect to SB plans, without compromising the achievement of clinical goals to OARs.

Keywords: Dose painting, biological imaging, proton therapy

References:

1. Buizza G, Paganelli C, Ballati F, et al. Improving the characterization of meningioma microstructure in proton therapy from conventional apparent diffusion coefficient measurements using Monte Carlo simulations of diffusion MRI. Med Phys. 2021;48(3):1250-1261. doi:10.1002/mp.14689 2. Morelli L, Buizza G, Paganelli C, et al. A Microstructure Model from Conventional Diffusion MRI of Meningiomas: Impact of Noise and Error Minimization. In: Cetin-Karayumak S, Christiaens D, Figini M, et al., eds. Computational Diffusion MRI. Springer International Publishing; 2021:25-35. doi:10.1007/978-3-030-87615-9_3 3. Bowen SR, Flynn RT, Bentzen SM, Jeraj R. On the sensitivity of IMRT dose optimization to the mathematical form of a biological imaging-based prescription function. Phys Med Biol. 2009;54(6):1483-1501. doi:10.1088/0031 9155/54/6/007 4. Iannalfi A, D’Ippolito E, Riva G, et al. Proton and carbon ion radiotherapy in skull base chordomas: a prospective study based on a dual particle and a patient-customized treatment strategy. Neuro Oncol. 2020;22(9):1348-1358. doi:10.1093/neuonc/noaa067

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