ESTRO 2024 - Abstract Book

S4662

Physics - Optimisation, algorithms and applications for ion beam treatment planning

ESTR0 2024

Conclusion:

The use of LET d optimization of large SC resulted in an increase of LET d in the GTV and CTV, while preserving robust OARs sparing and target coverage. The increase to the volume fraction receiving high dose from high-LET particles is expected to have a significant radiobiological effect and potentially increase the effectiveness of the treatments, especially for hypoxic targets.

Keywords: LET optimization, carbon ions, treatment planning

References:

1.

Tinganelli, W.; Durante, M. Carbon Ion Radiobiology. Cancers (Basel) 2020, 12, 3022,

doi:10.3390/cancers12103022.