ESTRO 2024 - Abstract Book

S4688

Physics - Optimisation, algorithms and applications for ion beam treatment planning

ESTR0 2024

Specifically, Table 1 provides a synthetic summary of the robustness methods used in publications focusing on a particular tumor site. It can be observed that most of the selected publications implemented robustness evaluation against setup and range errors (around 85%). About 21% of the papers report the implementation of some form of probabilistic evaluation. Most sources of uncertainties are well represented, except perhaps radiobiological effectiveness and linear energy transfer (LET) which amounts to only 8% of the selected publications. Intra-fraction motion and interplay effect are considered in 85% and 46% of lung studies, respectively, and in 33% of studies related to the treatment of targets in the mediastinum.

Worst case

Site

Publ

Prob

SE

RE

Inter-F

Intra-F

IP

RBE-LET

#

(% of publications per clinical site)

Head and neck 21

76

33

90

90

57

0

0

5

Brain and skull 9

56

44

100

78

33

0

0

22

Breast

5

80

20

100

100

40

60

0

20

Lung

26

85

23

88

88

27

85

46

8

Esophagus

9

89

11

89

89

56

78

33

0

Mediastinum

3

67

0

67

67

67

33

33

0

Abdomen and pelvis

19

74

0

74

74

42

32

26

5

All sites

92

77

21

87

85

42

63*

34*

8

Table 1 Summary of the robustness parameters used in clinical studies according to clinical sites. Extensive summary can be found in the appendix. Publ: Publications; Prob: Probabilistic; SE: Setup Errors; Inter-F: Inter-Fraction; Intra-F: Intra-Fraction; IP: Interplay effect