ESTRO 2024 - Abstract Book

S4703

Physics - Optimisation, algorithms and applications for ion beam treatment planning

ESTR0 2024

Figure 2. Plan recalculation dose on rv-CT2 for the two approaches for relevant OAR and target. Including additional imaging in rob_plan optimization provided comparable dosimetric results in terms of robustness to anatomical variations at the cost of significant longer computational time.

Keywords: Gynaecological tumor, PT, robustness and adaptive

References:

[1] Fredriksson A, Forsgren A, Hårdemark B. Minimax optimization for handling range and setup uncertainties in proton therapy. Med Phys. 2011 Mar;38(3):1672-84. doi: 10.1118/1.3556559. PMID: 21520880.

[2] Molinelli S, Vai A, Russo S, Loap P, Meschini G, Paganelli C, Barcellini A, Vitolo V, Orlandi E, Ciocca M. The role of multiple anatomical scenarios in plan optimization for carbon ion radiotherapy of pancreatic cancer. Radiother Oncol. 2022 Nov;176:1-8. doi: 10.1016/j.radonc.2022.09.005. Epub 2022 Sep 14. PMID: 36113776. [3] Meschini G, Vai A, Barcellini A, Fontana G, Molinelli S, Mastella E, Pella A, Vitolo V, Imparato S, Orlandi E, Ciocca M, Baroni G, Paganelli C. Time-resolved MRI for off-line treatment robustness evaluation in carbon-ion radiotherapy of pancreatic cancer. Med Phys. 2022 Apr;49(4):2386-2395. doi: 10.1002/mp.15510. Epub 2022 Feb 17. PMID: 35124811; PMCID: PMC9306947. [4] Yang Z, Zhang X, Wang X, Zhu XR, Gunn B, Frank SJ, Chang Y, Li Q, Yang K, Wu G, Liao L, Li Y, Chen M, Li H. Multiple CT optimization: An adaptive optimization method to account for anatomical changes in intensity-modulated proton therapy for head and neck cancers. Radiother Oncol. 2020 Jan;142:124-132. doi: 10.1016/j.radonc.2019.09.010. Epub 2019 Sep 26. PMID: 31564553; PMCID: PMC8564505.

2791

Proffered Paper

A novel proton GRID method via scissor beams with peak-valley-dose-ratio optimization

Weijie Zhang 1 , Erik Traneus 2 , Yuting Lin 1 , Ronald C Chen 1 , Hao Gao 1

1 University of Kansas Medical Center, Radiation Oncology, Kansas City, USA. 2 RaySearch Laboratories AB, NA, Stockholm, Sweden