ESTRO 2024 - Abstract Book

S4965

Physics - Radiomics, functional and biological imaging and outcome prediction

ESTRO 2024

Figure 2: The four patient cases. The clinical GTVs (red contour, contour shown only for the largest lesion) were delineated on the T1-weighted post-gadolinium image and transferred to other images with rigid registration. The ΔADC maps show diffusion time dependence, indicating restricted diffusion (negative signal) and substantial water exchange (positive signal).

Conclusion:

TDD-MRI on a clinical 1.5 T MR sim showed time-dependent ADC changes within the tumor volume showing both areas of restricted diffusion and areas of substantial water exchange, providing indications about cell sizes and cell density, and membrane permeability, respectively. The results indicate that TDD-MRI has potential to assess tumor heterogeneity for biologically adapted radiotherapy on clinical 1.5 T MR sim systems.

Keywords: time-dependent diffusion MRI, tumor heterogeneity

References: